PMID- 17212706
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20220330
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69
IP  - 1
DP  - 2007 Jan
TI  - Childhood asthma and human leukocyte antigen type.
PG  - 38-46
AB  - Little is known about the relationship between human leukocyte antigen (HLA) 
      class II genes and family history of asthma or atopy in relation to the incidence 
      of childhood asthma. The objective of the study was to determine whether specific 
      HLA class II genes (e.g., DRB1*03) are associated with asthma and whether such 
      association explains the influences of family history of asthma or atopy on 
      asthma incidence. A stratified random sample of 340 children who had HLA data 
      available from the Rochester Family Measles Study cohort (n= 876) and a 
      convenience sample of healthy children aged 5-12 years were the participants. We 
      conducted comprehensive medical record reviews to determine asthma status of 
      these children. The associations between the presence of specific HLA alleles and 
      development of asthma and the role of family history of asthma or atopy in the 
      association were evaluated by fitting Cox models. The cumulative incidence of 
      asthma by 12 years of age among children who carry HLA DRB1*03 was 33%, compared 
      to 24.2% among those who did not carry this allele. Adjusting for family history 
      of asthma or atopy, gender, low birth weight, season of birth, HLA DRB1*04, and 
      HLA DQB1*0302, the hazards ratio for HLA DRB1*03 carriers was 1.8 (95% confidence 
      interval: 1.1-2.9, P= 0.020). We concluded that the HLA DRB1*03 allele is 
      associated with asthma. However, the HLA class II gene does not explain the 
      influences of family history of asthma or atopy on development of asthma. The 
      mechanism underlying the association between asthma and HLA genes needs to be 
      elucidated.
FAU - Juhn, Y J
AU  - Juhn YJ
AD  - Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 
      55905, USA. juhn.young@mayo.edu
FAU - Kita, H
AU  - Kita H
FAU - Lee, L A
AU  - Lee LA
FAU - Smith, R W
AU  - Smith RW
FAU - Bagniewski, S M
AU  - Bagniewski SM
FAU - Weaver, A L
AU  - Weaver AL
FAU - Pankratz, V S
AU  - Pankratz VS
FAU - Jacobson, R M
AU  - Jacobson RM
FAU - Poland, G A
AU  - Poland GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-D Antigens)
SB  - IM
MH  - Adolescent
MH  - Asthma/*genetics/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-D Antigens/classification/*genetics/*immunology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Retrospective Studies
EDAT- 2007/01/11 09:00
MHDA- 2007/03/21 09:00
CRDT- 2007/01/11 09:00
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - TAN719 [pii]
AID - 10.1111/j.1399-0039.2006.00719.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Jan;69(1):38-46. doi: 10.1111/j.1399-0039.2006.00719.x.