PMID- 17212707
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20071115
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69
IP  - 1
DP  - 2007 Jan
TI  - Human MHC region harbors both susceptibility and protective haplotypes for 
      coronary artery disease.
PG  - 47-55
AB  - Aiming to study the role of human major histocompatibility complex (MHC) region 
      on coronary artery disease (CAD), we enrolled two separate patient materials and 
      controls. First, heart transplantation recipients (n = 276) were divided into 
      three subgroups according to the severity of atherosclerosis. The human leukocyte 
      antigen (HLA)-A-B-DR haplotype and gene frequencies were compared between groups. 
      Second, patients with acute coronary syndrome (ACS) (n = 100) and healthy 
      controls (n = 74) were assessed by nine genetic MHC markers (HLA-A, HLA-B, 
      HLA-DRB1, LTA+253(a/g), LTA+496(C/T), LTA+633(c/g), LTA+724(C/A), C4A and C4B), 
      and the frequencies were compared. In the heart transplantation recipients, 
      HLA-DR1 was strongly associated with CAD [severe vs no evidence, odds ratio (OR) 
      2.37; 95% confidence interval (CI) 1.33-4.25; P = 0.003]. Similarly, in the 
      patients with ACS, HLA-DRB1*01 was associated with CAD (patients vs controls, OR 
      2.36; 95% CI 1.25-4.44; P = 0.007). HLA-DRB1*01 was associated with 
      low-density-lipoprotein cholesterol (OR 5.32; 95% CI 1.64-17.26; P = 0.005) and 
      smoking habit (OR 3.13; 95% CI 1.09-9.03; P = 0.035) as risk factors. The 
      strongest protective gene was HLA-B*07 alone (OR 0.46; 95% CI 0.24-0.88; P = 
      0.02) or together with the haplotype LTA+253a-LTA+633g-C4A3-C4B1 (OR 0.36; 95% CI 
      0.22-0.57; P = 0.00001). In conclusion, human MHC region harbors genes that 
      protect from and predispose to CAD.
FAU - Palikhe, A
AU  - Palikhe A
AD  - Division of Cardiology, Department of Medicine, Helsinki University Central 
      Hospital, Helsinki, Finland.
FAU - Sinisalo, J
AU  - Sinisalo J
FAU - Seppanen, M
AU  - Seppanen M
FAU - Valtonen, V
AU  - Valtonen V
FAU - Nieminen, M S
AU  - Nieminen MS
FAU - Lokki, M L
AU  - Lokki ML
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Coronary Artery Disease/genetics/*immunology/*prevention & control
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 2007/01/11 09:00
MHDA- 2007/03/21 09:00
CRDT- 2007/01/11 09:00
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - TAN735 [pii]
AID - 10.1111/j.1399-0039.2006.00735.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Jan;69(1):47-55. doi: 10.1111/j.1399-0039.2006.00735.x.