PMID- 17213025
OWN - NLM
STAT- MEDLINE
DCOM- 20070220
LR  - 20220409
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 172
IP  - 2
DP  - 2007 Jan 15
TI  - Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of 
      cyclin D1.
PG  - 154-7
AB  - We report a case of acute myeloid leukemia (AML) subtype M2, with 
      t(5;11)(q35;q13), in a 30-year-old man. Conventional cytogenetic, spectral 
      karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow 
      sample obtained at diagnosis revealed an abnormal karyotype in all cells 
      examined. FISH analysis demonstrated absence of translocations in the region of 
      the cyclin D1 gene and real-time quantitative reverse transcriptase-polymerase 
      chain reaction revealed normal expression of this gene. Similar to the 11q23 
      region, 11q13 changes can be found in both myeloid and lymphoid neoplasias with 
      different chromosomes serving as donors in translocations.
FAU - de Oliveira, Fabio Morato
AU  - de Oliveira FM
AD  - Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade 
      de Sao Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil.
FAU - Tone, Luiz Gonzaga
AU  - Tone LG
FAU - Simoes, Belinda Pinto
AU  - Simoes BP
FAU - Falcao, Roberto Passetto
AU  - Falcao RP
FAU - Brassesco, Maria Sol
AU  - Brassesco MS
FAU - Sakamoto-Hojo, Elza Tiemi
AU  - Sakamoto-Hojo ET
FAU - dos Santos, Guilherme Augusto Silva
AU  - dos Santos GA
FAU - Marinato, Andre Fiorin
AU  - Marinato AF
FAU - Jacomo, Rafael Henriques
AU  - Jacomo RH
FAU - Rego, Eduardo Magalhaes
AU  - Rego EM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 5/*genetics
MH  - Cyclin D1/*biosynthesis/*genetics
MH  - Gene Expression Regulation, Neoplastic/*genetics
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*genetics/metabolism
MH  - Leukemia, Myelomonocytic, Acute
MH  - Male
MH  - *Translocation, Genetic
EDAT- 2007/01/11 09:00
MHDA- 2007/02/21 09:00
CRDT- 2007/01/11 09:00
PHST- 2006/08/05 00:00 [received]
PHST- 2006/09/01 00:00 [revised]
PHST- 2006/09/06 00:00 [accepted]
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/02/21 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - S0165-4608(06)00606-6 [pii]
AID - 10.1016/j.cancergencyto.2006.09.004 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2007 Jan 15;172(2):154-7. doi: 
      10.1016/j.cancergencyto.2006.09.004.