PMID- 17213576
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20070110
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 31
IP  - 6
DP  - 2006 Dec
TI  - [Cross-sectional study of the relation between carboxypeptidase-H antibody and 
      islet beta cell function in patients with latent autoimmune diabetes in adults].
PG  - 825-9
AB  - OBJECTIVE: To explore the relation between carboxypeptidase-H antibody (CPH-Ab) 
      and islet beta cell function in patients with latent autoimmune diabetes in 
      adults (LADA) and to further confirm the diagnostic value of CPH-Ab for LADA. 
      METHODS: Five hundred and forty-five patients who were initially diagnosed as 
      Type 2 diabetes mellitus (T2DM) were tested with CPH-Ab and GAD-Ab by radioligand 
      assay (RLA). T2DM patients, according to CPH-Ab and GAD-Ab status, were divided 
      into CPH-Ab(+) group, GAD-Ab(+) group, and Ab(-) group to compare their islet 
      beta cell function [represented by fasting C-peptide (FCP) and 2h postprandial 
      C-peptide (2hCP)]. The relation between CPH-Ab and islet beta cell function in 
      LADA was analyzed. RESULTS: The fasting C-peptide level in CPH-Ab(+) patients was 
      between that of GAD-Ab(+) patients and that of Ab(-) patients (P<0.05), and the 
      difference was still significant when the 3 groups were stratified with duration 
      of disease (All P<0.05), but not with body mess index (all P>0.05). Corrected by 
      concomitant variables including age, age at onset, duration of disease, and sex, 
      the differences among the 3 groups were statistically significant (both P<0.001). 
      Among the 3 groups FCP was lower than Ab(-) group in CPH-Ab(+) (P<0.05) and both 
      FCP and PCP were lower than Ab(-) group in GAD-Ab(+) group (P<0.05 and P<0.01). 
      The proportions of patients with insulin deficiency in CPH-Ab(+), GAD-Ab(+), and 
      Ab(-) group were 27.6% (8/29), 48.1% (8/52) and 13.5% (54/400), respectively, 
      which were significantly different among the 3 groups (P<0.001). GAD-Ab, BMI, and 
      fasting blood glucose had effects on FCP and PCP in T2DM patients (All P<0.05), 
      while CPH-Ab did not enter the equation in multivariable stepwise regressive 
      analysis (P>0.05). CONCLUSION: The effect of CPH-Ab is less marked than that of 
      GAD-Ab on islet beta-cell function in LADA patients. The value of CPH-Ab for the 
      failure of islet beta-cell function in LADA should be determined prospectively.
FAU - Yang, Lin
AU  - Yang L
AD  - Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya 
      Hospital, Central South University, Changsha 410011, China.
FAU - Zhou, Zhi-guang
AU  - Zhou ZG
FAU - Huang, Gan
AU  - Huang G
FAU - Jin, Ping
AU  - Jin P
FAU - Qi, Hai-ying
AU  - Qi HY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Autoantibodies)
RN  - EC 3.4.17.10 (Carboxypeptidase H)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoantibodies/*blood
MH  - Carboxypeptidase H/*immunology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/blood/diagnosis/*immunology
MH  - Female
MH  - Humans
MH  - Insulin-Secreting Cells/*physiology
MH  - Male
MH  - Middle Aged
EDAT- 2007/01/11 09:00
MHDA- 2013/07/23 06:00
CRDT- 2007/01/11 09:00
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - 1672-7347(2006)06-0825-05 [pii]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Dec;31(6):825-9.