PMID- 17213650
OWN - NLM
STAT- MEDLINE
DCOM- 20070402
LR  - 20190911
IS  - 0916-8451 (Print)
IS  - 0916-8451 (Linking)
VI  - 71
IP  - 1
DP  - 2007 Jan
TI  - Induction of multiple cytokine secretion from RAW264.7 cells by alginate 
      oligosaccharides.
PG  - 238-41
AB  - We investigated the cytokine-inducing activities of guluronate (G3-G6) and 
      mannuronate (M3-M6) oligomers on RAW264.7 cells with the Bio-Plex assay system. 
      Relatively high levels of tumor necrosis factor-alpha (TNF-alpha), granulocyte 
      colony-stimulating factor (G-CSF), monocyte chemoattractant protein-1 (MCP-1), 
      regulated upon activation normal T cell expressed and secreted (RANTES), 
      granulocyte macrophage (GM)-CSF, and eotaxin were induced by alginate oligomers 
      to different extents depending on the oligomer structures, and low but 
      significant levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-9, and IL-13 
      were also induced. Throughout all cytokines tested, M-oligomers tended to be more 
      potent than G-oligomers in terms of cytokine induction, and this tendency was 
      evident in differences between G3 and M3.
FAU - Yamamoto, Yoshiko
AU  - Yamamoto Y
AD  - Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Japan.
FAU - Kurachi, Maki
AU  - Kurachi M
FAU - Yamaguchi, Kenichi
AU  - Yamaguchi K
FAU - Oda, Tatsuya
AU  - Oda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070107
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Alginates)
RN  - 0 (Cytokines)
RN  - 0 (Hexuronic Acids)
RN  - 0 (Oligosaccharides)
RN  - 8A5D83Q4RW (Glucuronic Acid)
SB  - IM
MH  - Alginates/*chemistry
MH  - Animals
MH  - Cell Line
MH  - Cytokines/biosynthesis/*metabolism
MH  - Glucuronic Acid/chemistry
MH  - Hexuronic Acids/chemistry
MH  - Mice
MH  - Monocytes/drug effects/metabolism
MH  - Oligosaccharides/*chemistry/*pharmacology
EDAT- 2007/01/11 09:00
MHDA- 2007/04/03 09:00
CRDT- 2007/01/11 09:00
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/04/03 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - JST.JSTAGE/bbb/60416 [pii]
AID - 10.1271/bbb.60416 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2007 Jan;71(1):238-41. doi: 10.1271/bbb.60416. Epub 
      2007 Jan 7.