PMID- 17213658
OWN - NLM
STAT- MEDLINE
DCOM- 20070402
LR  - 20220225
IS  - 0916-8451 (Print)
IS  - 0916-8451 (Linking)
VI  - 71
IP  - 1
DP  - 2007 Jan
TI  - Dendritic cell-tumor fusion vaccine prevents tumor growth in vivo.
PG  - 215-21
AB  - Dendritic cells (DCs) are potent antigen presenting cells that are uniquely 
      effective in generating primary immune responses. DCs that are manipulated to 
      present tumor antigens induce antitumor immunity in animal models and preclinical 
      human studies. A myriad of strategies have been developed to load tumor antigen 
      effectively onto DCs. DC-tumor fusion presents a spectrum of tumor-associated 
      antigens to helper T- and cytotoxic T-cell populations in the context of 
      DC-mediated costimulatory signals. In this study, fusion cells (FCs) were 
      generated with MCA-102 fibrosarcoma cells and murine bone marrow-derived myeloid 
      DCs. The FCs coexpressed the DC-derived MHC class II and costimulatory molecules. 
      The FCs also retained the functional properties of DCs and stimulated syngeneic T 
      cell proliferation and interferon-gamma (IFN-gamma) production. Significantly, 
      the results show that syngeneic T cells are primed by FCs to induce MHC class 
      I-dependent lysis of MCA-102 fibrosarcoma. These findings indicate that fusions 
      of tumor cells and DCs activate T-cell responses against syngeneic tumors.
FAU - Kim, Gi-Young
AU  - Kim GY
AD  - Faculty of Applied Marine Science, Cheju National University, South Korea. 
      immunkim@cheju.ac.kr
FAU - Chae, Ho-Jin
AU  - Chae HJ
FAU - Kim, Ki-Hyung
AU  - Kim KH
FAU - Yoon, Man-Soo
AU  - Yoon MS
FAU - Lee, Kyu-Sub
AU  - Lee KS
FAU - Lee, Chang-Min
AU  - Lee CM
FAU - Moon, Dong-Oh
AU  - Moon DO
FAU - Lee, Jun-Sik
AU  - Lee JS
FAU - Jeong, Young-Il
AU  - Jeong YI
FAU - Choi, Yung Hyun
AU  - Choi YH
FAU - Park, Yeong-Min
AU  - Park YM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070107
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Cancer Vaccines/*immunology
MH  - Cell Fusion
MH  - Cells, Cultured
MH  - Dendritic Cells/*cytology/*immunology
MH  - Disease Progression
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasms/*immunology/*pathology
MH  - Phenotype
MH  - T-Lymphocytes, Cytotoxic/immunology
EDAT- 2007/01/11 09:00
MHDA- 2007/04/03 09:00
CRDT- 2007/01/11 09:00
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/04/03 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - JST.JSTAGE/bbb/60517 [pii]
AID - 10.1271/bbb.60517 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2007 Jan;71(1):215-21. doi: 10.1271/bbb.60517. Epub 
      2007 Jan 7.