PMID- 17215440
OWN - NLM
STAT- MEDLINE
DCOM- 20070410
LR  - 20220419
IS  - 1046-6673 (Print)
IS  - 1046-6673 (Linking)
VI  - 18
IP  - 2
DP  - 2007 Feb
TI  - Antineutrophil cytoplasmic autoantibody-negative Pauci-immune crescentic 
      glomerulonephritis.
PG  - 599-605
AB  - Pauci-immune crescentic glomerulonephritis (CrGN) is one of the most common 
      causes of rapidly progressive glomerulonephritis. The majority of patients with 
      pauci-immune CrGN had circulating antineutrophil cytoplasmic autoantibody (ANCA). 
      However, patients with ANCA-negative pauci-immune CrGN were not investigated 
      fully. This study aimed to analyze the characteristics of this subgroup of 
      patients. Patients whose pauci-immune CrGN was diagnosed from 1997 to 2006 in one 
      center were studied retrospectively. The criteria of pauci-immune was defined as 
      "the intensity of glomerular immunoglobulins staining by direct 
      immunofluorescence assay in renal sections was negative to 1+ staining on a scale 
      of 0 to 4+." Clinical and pathologic characteristics were compared between 
      patients with and without ANCA. Among the 85 patients with pauci-immune CrGN, 28 
      (32.9%) were ANCA negative. Compared with the 57 ANCA-positive patients, the 
      ANCA-negative patients were much younger (39.7 +/- 17.0 versus 57.6 +/- 14.0 yr; 
      P < 0.001). The level of urinary protein and the prevalence of nephrotic syndrome 
      were significantly higher in ANCA-negative patients than that in ANCA-positive 
      patients (P < 0.01 and P < 0.001, respectively). However, the prevalence of 
      extrarenal involvement was significantly lower in ANCA-negative patients than 
      that in ANCA-positive patients. The renal survival was poorer in ANCA-negative 
      patients than that in ANCA-positive ones (P < 0.05). ANCA-negative pauci-immune 
      CrGN was not rare and might represent an independent disease entity from 
      ANCA-positive vasculitis.
FAU - Chen, Min
AU  - Chen M
AD  - Renal Division and Institute of Nephrology, Peking University First Hospital, 
      Beijing 100034, P.R. China. mhzhao@bjmu.edu.cn
FAU - Yu, Feng
AU  - Yu F
FAU - Wang, Su-Xia
AU  - Wang SX
FAU - Zou, Wan-Zhong
AU  - Zou WZ
FAU - Zhao, Ming-Hui
AU  - Zhao MH
FAU - Wang, Hai-Yan
AU  - Wang HY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070110
PL  - United States
TA  - J Am Soc Nephrol
JT  - Journal of the American Society of Nephrology : JASN
JID - 9013836
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Antibodies, Antineutrophil Cytoplasmic/*immunology
MH  - Antibody Specificity
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glomerulonephritis/*immunology/*pathology/urine
MH  - Humans
MH  - Kidney/*pathology
MH  - Male
MH  - Middle Aged
MH  - Proteinuria
EDAT- 2007/01/12 09:00
MHDA- 2007/04/11 09:00
CRDT- 2007/01/12 09:00
PHST- 2007/01/12 09:00 [pubmed]
PHST- 2007/04/11 09:00 [medline]
PHST- 2007/01/12 09:00 [entrez]
AID - ASN.2006091021 [pii]
AID - 10.1681/ASN.2006091021 [doi]
PST - ppublish
SO  - J Am Soc Nephrol. 2007 Feb;18(2):599-605. doi: 10.1681/ASN.2006091021. Epub 2007 
      Jan 10.