PMID- 17216123
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20191210
IS  - 1569-5794 (Print)
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 23
IP  - 5
DP  - 2007 Oct
TI  - Can late gadolinium enhancement by cardiovascular magnetic resonance identify 
      coronary artery disease as the etiology of new onset congestive heart failure?
PG  - 595-602
AB  - BACKGROUND: New left ventricular systolic dysfunction affects 500,000 Americans 
      and coronary artery disease (CAD) is responsible for two-thirds of cases. 
      Identifying CAD has both prognostic and therapeutic implications. We evaluated 
      the ability of late gadolinium enhancement (LGE) by cardiovascular magnetic 
      resonance imaging (CMR) to detect CAD as the etiology of recent onset congestive 
      heart failure (CHF). METHODS: CMR and LGE were performed in 26 patients with new 
      onset left ventricular systolic dysfunction. All patients received an x-ray 
      angiography for identification of CAD. Patients with an acute coronary syndrome 
      with troponin I > 1.0 ng/ml or a history of CAD were excluded. The presence and 
      distribution of LGE was evaluated. RESULTS: Significant coronary stenoses were 
      present in 5 of 26 patients (19%). LGE in an infarct pattern was found in 2 of 
      the 5 patients with CAD. Of the 21 patients without CAD, 2 had midwall 
      enhancement but none had evidence of LGE in an infarct pattern. CONCLUSIONS: When 
      present, LGE in an infarct pattern suggests CAD as the etiology of new onset CHF. 
      However, the absence of LGE does not exclude CAD as the underlying etiology. A 
      small proportion of patients with a nonischemic cause of new onset CHF have LGE 
      limited to the midwall.
FAU - Schietinger, Brian J
AU  - Schietinger BJ
AD  - Department of Medicine, Cardiovascular Division, University of Virginia Health 
      System, Lee Street, Box 800170, Charlottesville, VA 22908, USA.
FAU - Voros, Szilard
AU  - Voros S
FAU - Isbell, David C
AU  - Isbell DC
FAU - Meyer, Craig H
AU  - Meyer CH
FAU - Christopher, John M
AU  - Christopher JM
FAU - Kramer, Christopher M
AU  - Kramer CM
LA  - eng
GR  - R56 HL075792/HL/NHLBI NIH HHS/United States
GR  - T32 EB003841/EB/NIBIB NIH HHS/United States
GR  - T32 HL007355/HL/NHLBI NIH HHS/United States
GR  - T32 HL07355/HL/NHLBI NIH HHS/United States
GR  - R01 HL075792/HL/NHLBI NIH HHS/United States
GR  - HL075792/HL/NHLBI NIH HHS/United States
GR  - T32 EB003841-05/EB/NIBIB NIH HHS/United States
GR  - T32EB 003841-01/EB/NIBIB NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070110
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - *Contrast Media
MH  - Coronary Angiography
MH  - Coronary Stenosis/complications/*pathology/physiopathology
MH  - Female
MH  - *Gadolinium DTPA
MH  - Heart Failure/*etiology/pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Research Design
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Ventricular Function, Left
PMC - PMC2955991
MID - NIHMS113361
EDAT- 2007/01/12 09:00
MHDA- 2007/12/21 09:00
PMCR- 2010/10/16
CRDT- 2007/01/12 09:00
PHST- 2006/09/27 00:00 [received]
PHST- 2006/12/01 00:00 [accepted]
PHST- 2007/01/12 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/01/12 09:00 [entrez]
PHST- 2010/10/16 00:00 [pmc-release]
AID - 10.1007/s10554-006-9200-x [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2007 Oct;23(5):595-602. doi: 10.1007/s10554-006-9200-x. 
      Epub 2007 Jan 10.