PMID- 17217682
OWN - NLM
STAT- MEDLINE
DCOM- 20070821
LR  - 20131121
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 34
IP  - 9
DP  - 2006 Sep
TI  - [Correlation of hyponatremia with plasma renin activity, antidiuretic hormone and 
      brain natriuretic peptide in chronic heart failure].
PG  - 781-3
AB  - OBJECTIVE: To observe the changes of plasma renin activity, antidiuretic hormone 
      and brain natriuretic peptide in chronic heart failure (CHF) and their 
      correlation with hyponatremia. METHODS: Plasma levels of PRA, ADH, and BNP were 
      measured by radioimmunology in 76 CHF patients. Forty-one out of 76 CHF patients 
      with hyponatremia and 35 CHF patients without hyponatremia were identified by 
      serum sodium. The rates of rehospitalization within 3 months were compared in two 
      groups. RESULTS: Levels of plasma renin activity, ALD, and BNP in CHF patients 
      with hyponatremia were notably higher than those in patients without hyponatremia 
      classified by New York Heart Association (NYHA) grade II - IV: PRA [(2.7 +/- 1.0) 
      ng.ml(-1).h(-1) vs. (1.8 +/- 0.7) ng.ml(-1).h(-1), (4.3 +/- 1.2) ng.ml(-1).h(-1) 
      vs. (3.0 +/- 0.9) ng.ml(-1).h(-1), (5.6 +/- 1.3) ng.ml(-1).h(-1) vs. (3.5 +/- 
      1.1) ng.ml(-1).h(-1), respectively, P < 0.05], ADH [(59.7 +/- 17.4) ng/L vs. 
      (48.6 +/- 15.3) ng/L, (68.4 +/- 17.6) ng/L vs. (56.3 +/- 19.2) ng/L, (75.3 +/- 
      20.0) ng/L vs. (51.4 +/- 16.2) ng/L, respectively, P < 0.05] and BNP [(276.4 +/- 
      75.2) ng/L vs. (185.3 +/- 55.3) ng/L, (380.1 +/- 113.6) ng/L vs. (258.5 +/- 62.1) 
      ng/L, (564.0 +/- 125.2) ng/L vs. (405.3 +/- 102.9) ng/L, respectively, P < 0.05]. 
      In the simple regression analyses, hyponatremia was negative correlated with PRA, 
      ADH and BNP (r = -0.31, P < 0.05; r = -0.28, P < 0.05, r = -0.80, P < 0.01). The 
      rate of rehospitalization within 3 months in hyponatremia group was higher than 
      that in control group. CONCLUSIONS: There is relation of hyponatremia to the 
      changes of plasma renin activity, antidiuretic hormone and brain natriuretic 
      peptide in chronic heart failure. Hyponatremia may accelerate the excretion of 
      plasma PRA, ADH and BNP in chronic heart failure. Neuroendocrine activation in 
      patients of congestive heart failure with hyponatremia is higher than that of 
      normal natremia group.
FAU - Fu, Lu
AU  - Fu L
AD  - Department of Cardiology, First Clinical College of Harbin Medical University, 
      Harbin 150001, China.
FAU - Ge, Hai-long
AU  - Ge HL
FAU - Li, Jia
AU  - Li J
FAU - Chen, Guang-yuan
AU  - Chen GY
FAU - Li, Yuan-shi
AU  - Li YS
FAU - Xie, Rong-sheng
AU  - Xie RS
FAU - Fan, Chun-yan
AU  - Fan CY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 11000-17-2 (Vasopressins)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart Failure/*blood
MH  - Humans
MH  - Hyponatremia/*blood
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Renin/*blood
MH  - Sodium/blood
MH  - Vasopressins/*blood
EDAT- 2007/01/16 09:00
MHDA- 2007/08/22 09:00
CRDT- 2007/01/16 09:00
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/08/22 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Sep;34(9):781-3.