PMID- 17217930
OWN - NLM
STAT- MEDLINE
DCOM- 20070517
LR  - 20220318
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 61
IP  - 7
DP  - 2007 Apr 1
TI  - Brain-derived neurotrophic factor Val66Met and psychiatric disorders: 
      meta-analysis of case-control studies confirm association to substance-related 
      disorders, eating disorders, and schizophrenia.
PG  - 911-22
AB  - BACKGROUND: There is an increasing recognition that the pathophysiology of mental 
      disorders could be the result of deregulation of synaptic plasticity with 
      alterations of neurotrophins. The valine (Val)66-to-methionine (Met) variant, 
      located in the pro brain-derived neurotrophic factor (BDNF) sequence, has been 
      extensively studied through linkage and association approaches in several 
      psychiatric disorders. METHODS: We performed a meta-analysis restricted to 
      individual case-control studies in different categories of mental disorders and 
      BDNF Val66Met polymorphism. We included data from 39 case-control studies 
      encompassing psychiatric phenotypes: eating disorders, substance-related 
      disorders, mood disorders, and schizophrenia, among others. RESULTS: The 
      association of Val66Met was confined to three diagnoses: substance-related 
      disorders, eating disorders, and schizophrenia. The Val/Met and the Met/Met 
      genotypes increase the risk for eating disorders up to 33%, while these same 
      genotypes confer a 21% protective effect in substance-related disorders. The 
      homozygous carriers Met/Met showed a 19% increased risk of schizophrenia with 
      respect to the heterozygous state. CONCLUSIONS: The study confirms the 
      association of Val66Met to substance-related disorders, eating disorders, and 
      schizophrenia. It remains to be determined if other variants in tight linkage 
      disequilibrium with Val66Met could configure an extended functional haplotype 
      that would explain observed discrepancies in risk estimations across studies.
FAU - Gratacos, Monica
AU  - Gratacos M
AD  - Genes and Disease Program, Center for Genomic Regulation (CRG), Psychiatry 
      Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
FAU - Gonzalez, Juan R
AU  - Gonzalez JR
FAU - Mercader, Josep M
AU  - Mercader JM
FAU - de Cid, Rafael
AU  - de Cid R
FAU - Urretavizcaya, Mikel
AU  - Urretavizcaya M
FAU - Estivill, Xavier
AU  - Estivill X
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20070109
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Feeding and Eating Disorders/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Mental Disorders/*genetics
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Schizophrenia/genetics
MH  - Substance-Related Disorders/genetics
MH  - Valine/*genetics
EDAT- 2007/01/16 09:00
MHDA- 2007/05/18 09:00
CRDT- 2007/01/16 09:00
PHST- 2006/03/14 00:00 [received]
PHST- 2006/06/29 00:00 [revised]
PHST- 2006/08/09 00:00 [accepted]
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/05/18 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
AID - S0006-3223(06)01072-9 [pii]
AID - 10.1016/j.biopsych.2006.08.025 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2007 Apr 1;61(7):911-22. doi: 10.1016/j.biopsych.2006.08.025. 
      Epub 2007 Jan 9.