PMID- 17217996
OWN - NLM
STAT- MEDLINE
DCOM- 20070404
LR  - 20171116
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 38
IP  - 3
DP  - 2007 Mar
TI  - Orbital marginal zone lymphomas: an immunohistochemical, polymerase chain 
      reaction, and fluorescence in situ hybridization study.
PG  - 435-42
AB  - Many studies have been performed on chromosomal aberrations of extranodal 
      marginal zone lymphomas. However, only a few have been published so far on ocular 
      adnexal marginal zone lymphomas. We studied 18 cases of orbital lymphoid cell 
      infiltrates. Using fluorescence in situ hybridization (FISH), we studied some of 
      the most common chromosomal aberrations found in extranodal marginal zone 
      lymphomas as: trisomies 3, and rearrangements of the 18q21 MALTI gene to detect 
      the translocations t(11;18)(q21;q21) and t(14;18)(q32;q21)MALT1. Our goals were 
      as follows: (1) study those aberrations in our material and compare them with the 
      literature, (2) check their prognostic significance, and (3) check whether 
      studying those aberrations with FISH can be used as a diagnostic tool to 
      differentiate reactive from neoplastic infiltrates, in addition to 
      immunohistochemistry and polymerase chain reaction. We found a high frequency of 
      trisomies 3 (68%) and 18 (56.6%), the highest published so far in orbital 
      lymphomas. On the other hand, no rearrangement was seen in any of our cases. The 
      histologic picture and the clinical course were the same when there was one or 
      more aberrations. As for the diagnostic significance, the presence of a prior, 
      concurrent, or subsequent lymphoma in almost all the positive for aberrations 
      cases suggests that either the orbital infiltrates in these cases are lymphomas, 
      or they have, at least, a malignant potential or a genetic instability. 
      Therefore, the demonstration of these numerical aberrations by FISH may be an 
      additional sensitive, reliable, and relatively simple tool to differentiate 
      reactive from neoplastic orbital lymphoid cell infiltrates when the 
      immunohistochemistry and polymerase chain reaction, performed in a busy and 
      routine-based histopathology laboratory, are unsatisfactory.
FAU - Schiby, Ginette
AU  - Schiby G
AD  - Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Sheba 
      Medical Center, Tel Hashomer 52621, Israel. gschiby@yahoo.com
FAU - Polak-Charcon, Sylvie
AU  - Polak-Charcon S
FAU - Mardoukh, Corine
AU  - Mardoukh C
FAU - Rosenblatt, Kinneret
AU  - Rosenblatt K
FAU - Goldberg, Iris
AU  - Goldberg I
FAU - Kneller, Abraham
AU  - Kneller A
FAU - Rosner, Mordechai
AU  - Rosner M
FAU - Kopolovic, Juri
AU  - Kopolovic J
LA  - eng
PT  - Journal Article
DEP - 20070110
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Neoplasm Proteins)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Caspases/genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Chromosomes, Human, Pair 3/genetics
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma/*genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - Neoplasm Proteins/genetics
MH  - Orbital Neoplasms/*genetics/*pathology
MH  - Polymerase Chain Reaction
MH  - Trisomy/genetics/pathology
EDAT- 2007/01/16 09:00
MHDA- 2007/04/05 09:00
CRDT- 2007/01/16 09:00
PHST- 2006/05/03 00:00 [received]
PHST- 2006/08/29 00:00 [revised]
PHST- 2006/09/01 00:00 [accepted]
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/04/05 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
AID - S0046-8177(06)00562-4 [pii]
AID - 10.1016/j.humpath.2006.09.007 [doi]
PST - ppublish
SO  - Hum Pathol. 2007 Mar;38(3):435-42. doi: 10.1016/j.humpath.2006.09.007. Epub 2007 
      Jan 10.