PMID- 17218388
OWN - NLM
STAT- MEDLINE
DCOM- 20070605
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 109
IP  - 9
DP  - 2007 May 1
TI  - TLR ligands differentially affect uptake and presentation of cellular antigens.
PG  - 3890-4
AB  - Dendritic cells (DCs) have the unique ability to efficiently present T-cell 
      epitopes from exogenous antigens on MHC class I molecules, a process called 
      cross-presentation. In our study we demonstrate that stimulation of 
      monocyte-derived DCs with Toll-like receptor (TLR) ligands differentially affects 
      the uptake and cross-presentation of cellular antigens. Activation of DCs with 
      TLR3 or TLR4 but not with TLR2 or TLR7/8 ligands inhibited phagocytosis of 
      apoptotic tumor cells and resulted in a reduced cross-presentation of 
      pp65-derived T-cell epitopes on MHC class I molecules upon engulfment of 
      cytomegalovirus (CMV)-infected fibroblasts. These results have an important 
      impact on the understanding of the interactions between the immune system and 
      pathogens and the development of vaccination strategies to treat malignant 
      diseases.
FAU - Weck, Markus Michael
AU  - Weck MM
AD  - Department of Oncology, Hematology, Immunology, Rheumatology and Pulmology, 
      Internal Medicine II, Institute of Medical Virology, University of Tubingen, 
      Otfried-Muller-Strasse 10, 72076 Tubingen, Germany.
FAU - Grunebach, Frank
AU  - Grunebach F
FAU - Werth, Daniela
AU  - Werth D
FAU - Sinzger, Christian
AU  - Sinzger C
FAU - Bringmann, Anita
AU  - Bringmann A
FAU - Brossart, Peter
AU  - Brossart P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070111
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Phosphoproteins)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (Viral Matrix Proteins)
RN  - 0 (cytomegalovirus matrix protein 65kDa)
SB  - IM
MH  - *Antigen Presentation
MH  - Apoptosis/immunology
MH  - Cell Line
MH  - Cytomegalovirus/immunology
MH  - Cytomegalovirus Infections/*immunology/therapy
MH  - Dendritic Cells/*immunology
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - Fibroblasts/immunology/virology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Monocytes/immunology
MH  - Neoplasms/*immunology/therapy
MH  - Phosphoproteins/immunology
MH  - Toll-Like Receptors/*immunology
MH  - Vaccination
MH  - Viral Matrix Proteins/immunology
EDAT- 2007/01/16 09:00
MHDA- 2007/06/06 09:00
CRDT- 2007/01/16 09:00
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/06/06 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
AID - S0006-4971(20)41637-4 [pii]
AID - 10.1182/blood-2006-04-015719 [doi]
PST - ppublish
SO  - Blood. 2007 May 1;109(9):3890-4. doi: 10.1182/blood-2006-04-015719. Epub 2007 Jan 
      11.