PMID- 17219016
OWN - NLM
STAT- MEDLINE
DCOM- 20071004
LR  - 20181113
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 114
IP  - 4
DP  - 2007
TI  - No evidence for preferential transmission of common valine allele of the Val66Met 
      polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD.
PG  - 523-6
AB  - Attention deficit/hyperactivity disorder (ADHD) is a highly heritable common 
      neurodevelopmental disorder with onset in childhood. A coding SNP (rs6265, 
      Val66Met) of the brain-derived neurotrophic factor gene (BDNF) has recently been 
      associated with ADHD. More specifically, paternal over-transmission of the common 
      Val66 allele to affected children had been observed. We aimed to confirm these 
      findings in a large, sufficiently powered, and well characterized German ADHD 
      family sample. The Val66Met polymorphism of BDNF was genotyped in 294 families 
      comprising one or more affected sibs (468 children). Contrary to previous 
      reports, we did not observe over-transmission of the common Val66 allele, from 
      either parent to affected children. We did not find support for an involvement of 
      the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD 
      in our sample.
FAU - Schimmelmann, B G
AU  - Schimmelmann BG
AD  - Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, 
      University of Duisburg-Essen, Essen, Germany.
FAU - Friedel, S
AU  - Friedel S
FAU - Dempfle, A
AU  - Dempfle A
FAU - Warnke, A
AU  - Warnke A
FAU - Lesch, K P
AU  - Lesch KP
FAU - Walitza, S
AU  - Walitza S
FAU - Renner, T J
AU  - Renner TJ
FAU - Romanos, M
AU  - Romanos M
FAU - Herpertz-Dahlmann, B
AU  - Herpertz-Dahlmann B
FAU - Linder, M
AU  - Linder M
FAU - Schafer, H
AU  - Schafer H
FAU - Seitz, C
AU  - Seitz C
FAU - Palmason, H
AU  - Palmason H
FAU - Freitag, C
AU  - Freitag C
FAU - Meyer, J
AU  - Meyer J
FAU - Konrad, K
AU  - Konrad K
FAU - Hinney, A
AU  - Hinney A
FAU - Hebebrand, J
AU  - Hebebrand J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070115
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Attention Deficit Disorder with Hyperactivity/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Pedigree
MH  - *Polymorphism, Single Nucleotide
MH  - Valine/genetics
EDAT- 2007/01/16 09:00
MHDA- 2007/10/05 09:00
CRDT- 2007/01/16 09:00
PHST- 2006/06/27 00:00 [received]
PHST- 2006/12/04 00:00 [accepted]
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/10/05 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
AID - 10.1007/s00702-006-0616-1 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2007;114(4):523-6. doi: 10.1007/s00702-006-0616-1. Epub 
      2007 Jan 15.