PMID- 17219990
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20140625
VI  - 20
IP  - 21
DP  - 2006 Nov
TI  - [Expression of telomerase reverse transcriptase and its relationship with 
      expression of c-myc in laryngeal squamous cell carcinomas].
PG  - 963-6
AB  - OBJECTIVE: To investigate the expression of human telomerase reverse 
      transcriptase (hTERT) and c-myc and their relationship with clinicopathological 
      parameter in laryngeal squamous cell carcinoma (LSCC). METHOD: The expression of 
      hTERT protein and c-myc protein in 39 LSCC specimens and 10 vocal cord polyp 
      specimens were detected by immunohistochemistry. The correlation between the 
      expression of hTERT protein and c-myc protein and their relationship with 
      clinicopathological parameter were analyzed. RESULT: The positive rate of hTERT 
      protein and c-myc protein expression in 39 LSCC was 84.6% (33/39) and 82.1% 
      (32/39), respectively. The positive rate of hTERT protein and c-myc protein 
      expression in 10 vocal cord polyps was 0 (0/10) and 10.0% (1/10) respectively. 
      Statistical tests showed that hTERT and c-myc protein expression was 
      significantly higher in LSCC than that in vocal cord polyps. Spearman rank 
      correlation analysis revealed that the expression of c-myc protein was great 
      significantly related to that of hTERT protein (correlation coefficient r = 
      0.541, P < 0.01). No statistically association was observed among the frequency 
      of hTERT expression and TNM stages, degree of differentiation or lymph nodes 
      metastases. CONCLUSION: The activation of hTERT may be a key step in the 
      pathogenesis of LSCC and the expression of hTERT was associated significantly 
      with that of c-myc gene. C-myc is probably an important control factor in the 
      activation and regulation of hTERT expression.
FAU - Chen, Zhiling
AU  - Chen Z
AD  - Department of Otorhinolaryngology, Hangzhou Chinese Traditional Medical Hospital, 
      Hangzhou 310007, China. chenzl1202@hotmail.com
FAU - Wu, Zhenghu
AU  - Wu Z
FAU - Guo, Xing
AU  - Guo X
FAU - Wu, Zuliang
AU  - Wu Z
FAU - Jiang, Manger
AU  - Jiang M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Polyps/pathology
MH  - Proto-Oncogene Proteins c-myc/genetics/*metabolism
MH  - Telomerase/genetics/*metabolism
MH  - Vocal Cords/pathology
EDAT- 2007/01/16 09:00
MHDA- 2011/04/16 06:00
CRDT- 2007/01/16 09:00
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Nov;20(21):963-6.