PMID- 17222250
OWN - NLM
STAT- MEDLINE
DCOM- 20071003
LR  - 20071115
IS  - 0309-0167 (Print)
IS  - 0309-0167 (Linking)
VI  - 50
IP  - 2
DP  - 2007 Jan
TI  - Cytogenetic abnormalities in MALT lymphomas and their precursor lesions from 
      different organs. A fluorescence in situ hybridization (FISH) study.
PG  - 217-24
AB  - AIMS: To analyse the possible activation of distinct molecular pathways in 
      mucosa-associated lymphoid tissue (MALT) lymphoma, we determined the prevalence 
      of trisomies 3, 12, 18 in MALT lymphomas from different organs, as well as the 
      prevalence of translocations of the MALT1 gene in a subset of primary breast MALT 
      lymphomas. We compared the numerical cytogenetic alterations in lymphomas, 
      precursor lesions and in normal non-haematolymphoid tissue from the same organs. 
      METHODS AND RESULTS: Forty-two samples of paraffin-embedded tissue (29 MALT 
      lymphomas from stomach, breast, parotid and thyroid; two Sjogren's syndrome; two 
      Hashimoto's thyroiditis and nine reactive samples) were studied by fluorescence 
      in situ hybridization (FISH). Analysed together, the cases of gastric, parotid 
      and thyroid MALT lymphomas presented trisomy 3 in 46%, trisomy 12 in 28% and 
      trisomy 18 in 21% of the cases. In contrast to other locations, trisomy 3 was not 
      present in the majority of the cases of primary breast MALT lymphomas. None of 
      the nine breast cases presented MALT1 gene rearrangements. Half of the cases of 
      preneoplastic lesions exhibited trisomy 3 and trisomy 12; none exhibited trisomy 
      18. CONCLUSIONS: Trisomy 3 is the most frequent numerical abnormality in gastric, 
      parotid and thyroid but not in primary breast MALT lymphomas. MALT1 gene 
      rearrangements are also rare in this location, suggesting that distinct molecular 
      pathways may be activated in breast cases.
FAU - Joao, C
AU  - Joao C
AD  - Department of Haematology, Portuguese Institute of Oncology, Lisbon, Portugal. 
      joao.cristinamaria@mayo.edu
FAU - Farinha, P
AU  - Farinha P
FAU - da Silva, M G
AU  - da Silva MG
FAU - Martins, C
AU  - Martins C
FAU - Crespo, M
AU  - Crespo M
FAU - Cabecadas, J
AU  - Cabecadas J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
SB  - IM
MH  - *Chromosome Aberrations
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/*pathology
MH  - Trisomy
EDAT- 2007/01/16 09:00
MHDA- 2007/10/04 09:00
CRDT- 2007/01/16 09:00
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/10/04 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
AID - HIS2580 [pii]
AID - 10.1111/j.1365-2559.2007.02580.x [doi]
PST - ppublish
SO  - Histopathology. 2007 Jan;50(2):217-24. doi: 10.1111/j.1365-2559.2007.02580.x.