PMID- 17222482
OWN - NLM
STAT- MEDLINE
DCOM- 20080428
LR  - 20080328
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 29
IP  - 5
DP  - 2008 May
TI  - BDNF genotype potentially modifying the association between incident stroke and 
      depression.
PG  - 789-92
AB  - OBJECTIVE: To investigate the role of the brain-derived neurotrophic factor 
      (BDNF) gene val66met polymorphism in the association between stroke and 
      depression. METHOD: Five hundred community residents aged >65 years without 
      stroke or depression at baseline were re-evaluated after 2 years. Disability 
      (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive 
      function (Mini-Mental State Examination, MMSE), and BDNF genotype were also 
      measured at baseline. RESULTS: The association between incident stroke and 
      depression was strengthened progressively with increasing numbers of met alleles, 
      and was only significant in subjects with the met/met genotype after adjustment 
      for disability and cognitive function. CONCLUSION: The BDNF val66met polymorphism 
      may modify the association between stroke and depression.
FAU - Kim, Jae-Min
AU  - Kim JM
AD  - Department of Psychiatry and Depression Clinical Research Center, Chonnam 
      National University Medical School, Kwangju, Republic of Korea.
FAU - Stewart, Robert
AU  - Stewart R
FAU - Kim, Sung-Wan
AU  - Kim SW
FAU - Yang, Su-Jin
AU  - Yang SJ
FAU - Shin, Il-Seon
AU  - Shin IS
FAU - Kim, Young-Hoon
AU  - Kim YH
FAU - Yoon, Jin-Sang
AU  - Yoon JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070111
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Comorbidity
MH  - Depression/diagnosis/*epidemiology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - Genotype
MH  - Humans
MH  - Incidence
MH  - Korea/epidemiology
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Stroke/diagnosis/*epidemiology/*genetics
EDAT- 2007/01/16 09:00
MHDA- 2008/04/29 09:00
CRDT- 2007/01/16 09:00
PHST- 2006/05/26 00:00 [received]
PHST- 2006/11/22 00:00 [revised]
PHST- 2006/11/30 00:00 [accepted]
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2008/04/29 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
AID - S0197-4580(06)00444-1 [pii]
AID - 10.1016/j.neurobiolaging.2006.11.021 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2008 May;29(5):789-92. doi: 
      10.1016/j.neurobiolaging.2006.11.021. Epub 2007 Jan 11.