PMID- 17222504
OWN - NLM
STAT- MEDLINE
DCOM- 20070906
LR  - 20181113
IS  - 0303-7207 (Print)
IS  - 0303-7207 (Linking)
VI  - 265-266
DP  - 2007 Feb
TI  - In search of tumor suppressing functions of menin.
PG  - 34-41
AB  - Human hereditary tumor syndromes serve as an ideal model for studying molecular 
      pathways regulating tumorigenesis. Multiple endocrine neoplasia type 1 (MEN1), a 
      human familial tumor syndrome, results from mutations in the Men1 gene. Men1 
      encodes a novel tumor suppressor, menin, of unknown biochemical function. 
      Recently, significant progress has been made in identifying menin as a regulator 
      of gene transcription, cell proliferation, apoptosis, and genome stability, 
      leading to a new model of understanding menin's tumor-suppressing function. These 
      findings suggest that menin's diverse functions depend on its association with 
      chromatin and its control over gene transcription. This knowledge will likely be 
      translated into new strategies to improve therapeutic interventions against MEN1 
      and other related cancers.
FAU - Yang, Yuqing
AU  - Yang Y
AD  - Abramson Family Cancer Research Institute, Signal Transduction Program, 
      Department of Cancer Biology, University of Pennsylvania School of Medicine, 
      Philadelphia, PA 19104-6160, USA.
FAU - Hua, Xianxin
AU  - Hua X
LA  - eng
GR  - R01 CA100912/CA/NCI NIH HHS/United States
GR  - R01 CA113962/CA/NCI NIH HHS/United States
GR  - CA113962/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070111
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cell Proliferation
MH  - *Gene Expression Regulation, Neoplastic
MH  - Genes, Tumor Suppressor
MH  - Genomic Instability
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/genetics/metabolism
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Tumor Suppressor Proteins/genetics/*metabolism
PMC - PMC1919399
MID - NIHMS19361
EDAT- 2007/01/16 09:00
MHDA- 2007/09/07 09:00
PMCR- 2008/02/26
CRDT- 2007/01/16 09:00
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/09/07 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
PHST- 2008/02/26 00:00 [pmc-release]
AID - S0303-7207(06)00589-2 [pii]
AID - 10.1016/j.mce.2006.12.032 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2007 Feb;265-266:34-41. doi: 10.1016/j.mce.2006.12.032. Epub 
      2007 Jan 11.