PMID- 17222539
OWN - NLM
STAT- MEDLINE
DCOM- 20070530
LR  - 20220330
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 90
IP  - 1-3
DP  - 2007 Feb
TI  - Functional disconnections in the direct and indirect amygdala pathways for fear 
      processing in schizophrenia.
PG  - 284-94
AB  - BACKGROUND: Schizophrenia patients show reduced neural activity, relative to 
      controls, in the amygdala and its projection to the medial prefrontal cortex 
      (MPFC) in response to fear perception. In this study we tested the hypothesis 
      that schizophrenia is characterized by abnormal functional connectivity in the 
      amygdala network underlying fear perception. METHODS: Functional MRI images were 
      acquired from 14 schizophrenia patients and 14 matched healthy control subjects 
      during an emotion perception task, in which fearful and neutral facial expression 
      stimuli were presented pseudorandomly under nonconscious (using masking) and 
      conscious conditions. Both subtraction and functional connectivity analyses were 
      undertaken using a region of interest approach. RESULTS: In response to fearful 
      facial expressions, schizophrenia patients displayed reduced amygdala activity, 
      compared to controls, in both the conscious and nonconscious conditions. The 
      amygdala displayed a reversal of the normal pattern of connectivity with the 
      brainstem, visual cortex, and also with the dorsal and ventral divisions of the 
      MPFC in the schizophrenia patients. CONCLUSIONS: The presence of functional 
      disconnections in amygdala pathways suggests that schizophrenia patients have a 
      failure in coordinating their automatic orienting to salient signals and the 
      associated prefrontal monitoring of these signals.
FAU - Das, Pritha
AU  - Das P
AD  - Neuroscience Institute of Schizophrenia and Allied Disorders, Darlinghurst, NSW 
      2010, Australia. prithad@psych.usyd.edu.au
FAU - Kemp, Andrew H
AU  - Kemp AH
FAU - Flynn, Gary
AU  - Flynn G
FAU - Harris, Anthony W F
AU  - Harris AW
FAU - Liddell, Belinda J
AU  - Liddell BJ
FAU - Whitford, Thomas J
AU  - Whitford TJ
FAU - Peduto, Anthony
AU  - Peduto A
FAU - Gordon, Evian
AU  - Gordon E
FAU - Williams, Leanne M
AU  - Williams LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070110
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adult
MH  - Amygdala/*physiopathology
MH  - Awareness/physiology
MH  - Brain Stem/physiopathology
MH  - Dominance, Cerebral/*physiology
MH  - Fear/*physiology
MH  - Female
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - *Imaging, Three-Dimensional
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/physiopathology
MH  - Prefrontal Cortex/*physiopathology
MH  - Schizophrenia/diagnosis/*physiopathology
MH  - *Schizophrenic Psychology
MH  - Superior Colliculi/physiopathology
MH  - Visual Cortex/physiopathology
EDAT- 2007/01/16 09:00
MHDA- 2007/05/31 09:00
CRDT- 2007/01/16 09:00
PHST- 2006/08/18 00:00 [received]
PHST- 2006/11/20 00:00 [revised]
PHST- 2006/11/25 00:00 [accepted]
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/05/31 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
AID - S0920-9964(06)00494-4 [pii]
AID - 10.1016/j.schres.2006.11.023 [doi]
PST - ppublish
SO  - Schizophr Res. 2007 Feb;90(1-3):284-94. doi: 10.1016/j.schres.2006.11.023. Epub 
      2007 Jan 10.