PMID- 17222766
OWN - NLM
STAT- MEDLINE
DCOM- 20070412
LR  - 20071203
IS  - 1083-8791 (Print)
IS  - 1083-8791 (Linking)
VI  - 13
IP  - 1 Suppl 1
DP  - 2007 Jan
TI  - Dendritic cells in transplantation and immune-based therapies.
PG  - 23-32
AB  - Dendritic cells (DCs) are specialized, bone marrow-derived leukocytes critical to 
      the onset of both innate and adaptive immunity. The divisions of labor among 
      distinct human DC subtypes achieve the most effective balance between 
      steady-state tolerance and the induction of innate and adaptive immunity against 
      pathogens, tumors, and other insults. Maintenance of tolerance in the steady 
      state is an active process involving resting or semimature DCs. Breakdowns in 
      this homeostasis can result in autoimmunity. Perturbation of the steady state 
      should first lead to the onset of innate immunity mediated by rapid responders in 
      the form of plasmacytoid and monocyte-derived DC stimulators and natural killer 
      (NK) and NK T-cell responders. These innate effectors then provide additional 
      inflammatory cytokines, including interferon-gamma, which support the activation 
      and maturation of resident and circulating populations of DCs. These are critical 
      to the onset and expansion of adaptive immunity, including Th1, Th2, and 
      cytotoxic T-lymphocyte responses. Rodent models are now revealing important data 
      about distinct DC precursors, homeostasis of tissue-resident DCs, and DC turnover 
      in response to inflammation and pathological conditions like graft-versus-host 
      disease. The use of defined DC subtypes to stimulate both innate and adaptive 
      immunity, either in combination or in a prime-boost vaccine sequence, may prove 
      most useful clinically by harnessing both effector cell compartments.
FAU - Young, James W
AU  - Young JW
AD  - Department of Medicine, Memorial Sloan-Kettering Cancer Center, Weill Medical 
      College of Cornell University, New York, New York 10021, USA. youngjw@mskcc.org
FAU - Merad, Miriam
AU  - Merad M
FAU - Hart, Derek N J
AU  - Hart DN
LA  - eng
GR  - P01 CA23766/CA/NCI NIH HHS/United States
GR  - P01 CA59350/CA/NCI NIH HHS/United States
GR  - R01 CA83070/CA/NCI NIH HHS/United States
GR  - R01-CA 112100/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation/immunology
MH  - Chimerism
MH  - Dendritic Cells/*immunology/transplantation
MH  - Graft vs Host Disease/*immunology/prevention & control
MH  - Graft vs Tumor Effect/immunology
MH  - Humans
MH  - *Immunotherapy, Adoptive
MH  - Mice
MH  - Transplantation, Homologous/immunology
RF  - 79
EDAT- 2007/01/16 09:00
MHDA- 2007/04/14 09:00
CRDT- 2007/01/16 09:00
PHST- 2007/01/16 09:00 [pubmed]
PHST- 2007/04/14 09:00 [medline]
PHST- 2007/01/16 09:00 [entrez]
AID - S1083-8791(06)00726-9 [pii]
AID - 10.1016/j.bbmt.2006.10.023 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2007 Jan;13(1 Suppl 1):23-32. doi: 
      10.1016/j.bbmt.2006.10.023.