PMID- 17224231
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20070723
IS  - 0301-2115 (Print)
IS  - 0301-2115 (Linking)
VI  - 133
IP  - 2
DP  - 2007 Aug
TI  - Is the polycystic ovary syndrome associated with chronic inflammation per se?
PG  - 197-202
AB  - OBJECTIVE: The aim of the present study was to evaluate serum concentrations of 
      tumor necrosis factor-alpha (TNF-alpha), TNF-soluble receptors, and IL-6 in obese 
      women without additional diseases and obese women with polycystic ovary syndrome 
      (PCOS). STUDY DESIGN: The study group consisted of 39 obese women with PCOS and 
      34 age-matched obese women without additional disease were included as controls. 
      Blood glucose, total cholesterol, HDL-cholesterol, and triglycerides were 
      measured by the enzymatic procedure. Plasma insulin, follicle-stimulating hormone 
      (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS), 
      androstenedione, total and free testosterone, cortisol, progesterone, 
      17OH-progesterone, estradiol, and sex hormone binding globulin (SHBG) were 
      measured by a commercial radioimmunoassay (RIA). Tumor necrosis factor-alpha 
      (TNF-alpha), soluble TNF receptors (sTNFRs), and IL-6 were determined by an 
      ELISA. RESULTS: We did not observe any differences in serum concentrations of 
      TNF-alpha between obese women with and without PCOS. Serum concentrations of 
      sTNFR1 and sTNFR2 were significantly higher in PCOS patients compared with 
      controls; however, serum concentrations of IL-6 were significantly lower in PCOS 
      patients. CONCLUSIONS: Our findings suggest that PCOS is not associated with 
      chronic inflammation.
FAU - Olszanecka-Glinianowicz, Magdalena
AU  - Olszanecka-Glinianowicz M
AD  - Department of Pathophysiology, Silesian University School of Medicine, Medykow 
      Street 18, 40-752 Katowice, Poland. magols@esculap.pl
FAU - Banas, Michal
AU  - Banas M
FAU - Zahorska-Markiewicz, Barbara
AU  - Zahorska-Markiewicz B
FAU - Janowska, Joanna
AU  - Janowska J
FAU - Kocelak, Piotr
AU  - Kocelak P
FAU - Madej, Pawel
AU  - Madej P
FAU - Klimek, Katarzyna
AU  - Klimek K
LA  - eng
PT  - Journal Article
DEP - 20070116
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Inflammation/diagnosis/*epidemiology
MH  - Interleukin-6/*blood
MH  - Obesity/complications
MH  - Polycystic Ovary Syndrome/*complications
MH  - Receptors, Tumor Necrosis Factor, Type I/*blood
MH  - Receptors, Tumor Necrosis Factor, Type II/*blood
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2007/01/17 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/01/17 09:00
PHST- 2005/06/03 00:00 [received]
PHST- 2006/10/05 00:00 [revised]
PHST- 2006/10/18 00:00 [accepted]
PHST- 2007/01/17 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/01/17 09:00 [entrez]
AID - S0301-2115(06)00665-8 [pii]
AID - 10.1016/j.ejogrb.2006.10.037 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2007 Aug;133(2):197-202. doi: 
      10.1016/j.ejogrb.2006.10.037. Epub 2007 Jan 16.