PMID- 17224407
OWN - NLM
STAT- MEDLINE
DCOM- 20070227
LR  - 20240109
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 53
IP  - 2
DP  - 2007 Jan 18
TI  - Persistence of long-term memory storage requires a late protein synthesis- and 
      BDNF- dependent phase in the hippocampus.
PG  - 261-77
AB  - Persistence is the most characteristic attribute of long-term memory (LTM). To 
      understand LTM, we must understand how memory traces persist over time despite 
      the short-lived nature and rapid turnover of their molecular substrates. It is 
      widely accepted that LTM formation is dependent upon hippocampal de novo protein 
      synthesis and Brain-Derived Neurotrophic Factor (BDNF) signaling during or early 
      after acquisition. Here we show that 12 hr after acquisition of a one-trial 
      associative learning task, there is a novel protein synthesis and BDNF-dependent 
      phase in the rat hippocampus that is critical for the persistence of LTM storage. 
      Our findings indicate that a delayed stabilization phase is specifically required 
      for maintenance, but not formation, of the memory trace. We propose that memory 
      formation and memory persistence share some of the same molecular mechanisms and 
      that recurrent rounds of consolidation-like events take place in the hippocampus 
      for maintenance of the memory trace.
FAU - Bekinschtein, Pedro
AU  - Bekinschtein P
AD  - Instituto de Biologia Celular y Neurociencias, UBA, Buenos Aires (C1121ABG), 
      Argentina.
FAU - Cammarota, Martin
AU  - Cammarota M
FAU - Igaz, Lionel Muller
AU  - Igaz LM
FAU - Bevilaqua, Lia R M
AU  - Bevilaqua LR
FAU - Izquierdo, Ivan
AU  - Izquierdo I
FAU - Medina, Jorge H
AU  - Medina JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/physiology
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Conditioning, Psychological/physiology
MH  - Fear
MH  - Learning/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/*physiology
MH  - Nerve Tissue Proteins/*biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Swimming
MH  - Time Factors
EDAT- 2007/01/17 09:00
MHDA- 2007/02/28 09:00
CRDT- 2007/01/17 09:00
PHST- 2006/04/03 00:00 [received]
PHST- 2006/09/20 00:00 [revised]
PHST- 2006/11/27 00:00 [accepted]
PHST- 2007/01/17 09:00 [pubmed]
PHST- 2007/02/28 09:00 [medline]
PHST- 2007/01/17 09:00 [entrez]
AID - S0896-6273(06)01026-9 [pii]
AID - 10.1016/j.neuron.2006.11.025 [doi]
PST - ppublish
SO  - Neuron. 2007 Jan 18;53(2):261-77. doi: 10.1016/j.neuron.2006.11.025.