PMID- 17226799
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20220318
IS  - 0265-9247 (Print)
IS  - 0265-9247 (Linking)
VI  - 29
IP  - 2
DP  - 2007 Feb
TI  - BDNF variant linked to anxiety-related behaviors.
PG  - 116-9
AB  - Brain-derived neurotrophic factor (BDNF) is the most-abundant neurotrophin in the 
      brain. In mammals, it is synthesized as a precursor called proBDNF, which is 
      proteolytically cleaved to generate mature BDNF. The BDNF gene is located on 
      chromosome 11p13, and a functional single nucleotide polymorphism (SNP) of this 
      gene has been shown to produce a valine (Val)-to-methionine (Met) substitution in 
      the proBDNF protein at codon 66 (Val66Met). Several papers suggest that this SNP 
      is related to decreased hippocampal volume and hippocampus-mediated memory 
      performance in humans. Recently, Chen et al. generated a variant BDNF mouse 
      (BDNF(Met/Met)) that reproduces the phenotypic hallmarks in humans with a variant 
      Met allele. In the behavioral analysis, BDNF(Met/Met) mice show increased 
      anxiety-related behaviors. This mini-review examines the impact of Met 
      substitution of proBDNF on anxiety-related behaviors.
CI  - Copyright 2007 Wiley Periodicals, Inc.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, 1-8-1 Inohana, Chiba 260-8670, Japan. hashimoto@faculty.chiba-u.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Bioessays
JT  - BioEssays : news and reviews in molecular, cellular and developmental biology
JID - 8510851
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Anxiety/*genetics
MH  - *Behavior
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Humans
MH  - Mental Disorders/*genetics
MH  - Polymorphism, Single Nucleotide
RF  - 31
EDAT- 2007/01/18 09:00
MHDA- 2007/03/14 09:00
CRDT- 2007/01/18 09:00
PHST- 2007/01/18 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2007/01/18 09:00 [entrez]
AID - 10.1002/bies.20534 [doi]
PST - ppublish
SO  - Bioessays. 2007 Feb;29(2):116-9. doi: 10.1002/bies.20534.