PMID- 1722753
OWN - NLM
STAT- MEDLINE
DCOM- 19920225
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 200
IP  - 1
DP  - 1991 Jul 23
TI  - Reduction in brain serotonin markers by alpha-ethyltryptamine (Monase).
PG  - 187-90
AB  - alpha-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a 
      monoamine releasing agent. To determine whether alpha-ethyltryptamine induces 
      serotonergic deficits similar to that of other monoamine releasing agents such as 
      3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats 
      were given multiple doses (8 x 30 mg/kg s.c.) of alpha-ethyltryptamine acetate. 
      Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT 
      uptake sites (determined from [3H]paroxetine binding) were significantly 
      decreased in frontal cortex samples at one week killing. A significant decrease 
      in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The 
      results provide evidence that alpha-ethyltryptamine may induce serotonin 
      neurotoxicity similar to that of MDMA and PCA.
FAU - Huang, X M
AU  - Huang XM
AD  - Purdue University, Department of Pharmacology and Toxicology, West Lafayette, IN 
      47907.
FAU - Johnson, M P
AU  - Johnson MP
FAU - Nichols, D E
AU  - Nichols DE
LA  - eng
GR  - DA-04758/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - 0 (Tryptamines)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - GR181O3R32 (etryptamine)
SB  - IM
MH  - Animals
MH  - Binding Sites/drug effects
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Hippocampus/*drug effects/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Monoamine Oxidase Inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*metabolism
MH  - Tryptamines/*pharmacology
EDAT- 1991/07/23 00:00
MHDA- 1991/07/23 00:01
CRDT- 1991/07/23 00:00
PHST- 1991/07/23 00:00 [pubmed]
PHST- 1991/07/23 00:01 [medline]
PHST- 1991/07/23 00:00 [entrez]
AID - 0014-2999(91)90686-K [pii]
AID - 10.1016/0014-2999(91)90686-k [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1991 Jul 23;200(1):187-90. doi: 10.1016/0014-2999(91)90686-k.