PMID- 17227817
OWN - NLM
STAT- MEDLINE
DCOM- 20070503
LR  - 20191210
IS  - 0007-0912 (Print)
IS  - 0007-0912 (Linking)
VI  - 98
IP  - 3
DP  - 2007 Mar
TI  - Predictive value of IL-18 and SC5b-9 for neurocognitive dysfunction after 
      cardiopulmonary bypass.
PG  - 317-22
AB  - BACKGROUND: Neurological injury after cardiopulmonary bypass (CPB) continues to 
      be a major problem after cardiac surgery. The aim of this study was to 
      investigate the predictive value of Interleukin-18 (IL-18) and SC5b-9 as 
      biochemical markers of neurocognitive dysfunction after cardiac surgery. METHODS: 
      A total of 30 patients undergoing elective cardiac surgery using CPB were 
      recruited. Blood samples were obtained for IL-18 and SC5b-9 concentrations before 
      induction, 24, 48, 72, 96 and 120 h post-CPB and 6 weeks after operation. In 
      addition, patients underwent a standard battery of neuropsychometric tests before 
      operation and at day 5 and 6 weeks after operation. RESULTS: Serum concentration 
      of IL-18, but not SC5b-9, was significantly different between patients with and 
      without neurocognitive dysfunction; serum IL-18 concentration significantly 
      increased in patients with neurocognitive dysfunction (P = 0.018). Neurological 
      outcome was significantly dependent on peak difference in IL-18 concentration at 
      day 5 (P = 0.033), but not on peak difference in SC5b-9 concentration (P = 0.16). 
      Eight patients had neurocognitive dysfunction at day 5 and three had 
      neurocognitive dysfunction at 6 weeks. In a very small number of patients, no 
      significant association was demonstrated between IL-18 or SC5b-9 concentrations 
      and neurocognitive dysfunction at 6 weeks. CONCLUSIONS: IL-18 has the potential 
      as a useful marker of neurological dysfunction, requiring further investigation.
FAU - Kumar, R A
AU  - Kumar RA
AD  - Department of Anaesthetics and Intensive Care Medicine, Wales College of 
      Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. 
      arunkumar@btinternet.com
FAU - Cann, C
AU  - Cann C
FAU - Hall, J E
AU  - Hall JE
FAU - Sudheer, P S
AU  - Sudheer PS
FAU - Wilkes, A R
AU  - Wilkes AR
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20070116
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - 0 (Biomarkers)
RN  - 0 (Complement Membrane Attack Complex)
RN  - 0 (Interleukin-18)
RN  - 0 (SC5b-9 protein complex)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
CIN - Br J Anaesth. 2007 Sep;99(3):444-5; author reply 444-5. PMID: 17702828
MH  - Aged
MH  - Biomarkers/blood
MH  - Cardiac Surgical Procedures
MH  - Cardiopulmonary Bypass/*adverse effects
MH  - Cognition Disorders/blood/*diagnosis/etiology
MH  - Complement Membrane Attack Complex
MH  - Complement System Proteins/*metabolism
MH  - Female
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Postoperative Period
MH  - Predictive Value of Tests
EDAT- 2007/01/18 09:00
MHDA- 2007/05/04 09:00
CRDT- 2007/01/18 09:00
PHST- 2007/01/18 09:00 [pubmed]
PHST- 2007/05/04 09:00 [medline]
PHST- 2007/01/18 09:00 [entrez]
AID - S0007-0912(17)34871-7 [pii]
AID - 10.1093/bja/ael366 [doi]
PST - ppublish
SO  - Br J Anaesth. 2007 Mar;98(3):317-22. doi: 10.1093/bja/ael366. Epub 2007 Jan 16.