PMID- 17228674
OWN - NLM
STAT- MEDLINE
DCOM- 20090611
LR  - 20111117
IS  - 1002-1892 (Print)
IS  - 1002-1892 (Linking)
VI  - 20
IP  - 12
DP  - 2006 Dec
TI  - [Determination on contents of matrix metalloproteinase 3 and interleukin 1 in 
      tissues of lumbar disc herniation and their roles in pathogenesis].
PG  - 1180-2
AB  - OBJECTIVE: To determine the contents of matrix metalloproteinase 3 (MMP-3) and 
      interleukin 1 (IL-1) in the tissues of the lumbar disc herniation and to 
      investigate their roles in the pathogenesis. METHODS: The tissues of the 
      herniated lumbar disc were obtained from 30 patients undergoing surgery for 
      persistent radiculopathy from June 2003 to December 2004 and at the same time 
      these samples were divided into the following three experimental groups: the 
      bulge group (n =11), the protrusion group (n = 9), and the prolapsus group (n = 
      10), 14 males, 16 females, aged 33-64 years. As the control group, 9 lumbar disc 
      specimens were harvested from 9 patients (4 males, 5 females, aged 21-58 years) 
      suffering from bursting fracture of the lumbar spine. The specimens were analyzed 
      by the ELISA method for the contents of MMP-3 and IL-1. RESULTS: The contents of 
      MMP-3(14.25+/-1. 32, 19.89+/-2.97, 20.69+/-2.18 ng/ml in the bulge group, 
      protrusion group and prolapsus group, separately) and IL-1 (8.52+/-0.22, 
      11.88+/-0.52, 11.90+/-0.73 pg/ml in the bulge group, protrusion group and 
      prolapsus group, separately) in the experimental groups were significantly higher 
      than those in the control group. The contents of MMP-3 and IL-1 in the protrusion 
      group were not significantly higher than those in the prolapsus group, but they 
      were significantly higher than those in the bulge group(P<0.01). The contents of 
      MMP-3 had a significant relationship with the contents of IL-1 in the three 
      experimental groups and the control group(P<0. 01). CONCLUSION: The result 
      demonstrates that the tissues of the lumbar disc herniation can produce both 
      MMP-3 and IL-1, which may have an unknown but important relationship with each 
      other.
FAU - Jia, Changqing
AU  - Jia C
AD  - Department of Orthopedic Surgery, Second Affiliated Hospital of China Medical 
      University, Shenyang Liaoning, 110001, PR China. jiachqzh@sina.com
FAU - Wang, Chen
AU  - Wang C
FAU - Chen, Yong
AU  - Chen Y
LA  - chi
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
JT  - Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = 
      Chinese journal of reparative and reconstructive surgery
JID - 9425194
RN  - 0 (Interleukin-1)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Interleukin-1/*metabolism
MH  - Intervertebral Disc/metabolism
MH  - Intervertebral Disc Displacement/*metabolism/pathology
MH  - Lumbar Vertebrae
MH  - Male
MH  - Matrix Metalloproteinase 3/*metabolism
MH  - Middle Aged
EDAT- 2007/01/19 09:00
MHDA- 2009/06/12 09:00
CRDT- 2007/01/19 09:00
PHST- 2007/01/19 09:00 [pubmed]
PHST- 2009/06/12 09:00 [medline]
PHST- 2007/01/19 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006 Dec;20(12):1180-2.