PMID- 17228733
OWN - NLM
STAT- MEDLINE
DCOM- 20090520
LR  - 20161124
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 23
IP  - 6
DP  - 2006 Dec
TI  - [Effects of salidroside on bone marrow matrix metalloproteinases of bone marrow 
      depressed anemic mice].
PG  - 1314-9
AB  - To examine the effect of salidroside on the expression and activities of matrix 
      metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in bone marrow 
      (BM) of BM depressed anemic mice by immunohistochemistry and gelatin zymography 
      respectively, and to explore its roles in hematopoietic regulation. 
      Immunohistochemistry showed that the expression of MMP-2 and MMP-9 of bone marrow 
      cells (BMCs) was found in each group. Compared with control group, the expression 
      of MMP-2 and MMP-9 was obviously increased in the model group, low-dose, 
      middle-dose and high-dose salidroside. At day 4 after treatment of radiation and 
      chemotherapy, the peak of the expression of MMP-2 and MMP-9 was found in 
      middle-dose salidroside . At day 8 after treatment of radiation and chemotherapy, 
      the peak of the expression of MMP-2 and MMP-9 was found in low-dose and 
      middle-dose salidroside respectively. Gelatin zymography revealed that 66 kD 
      proMMP-2, 62 kD MMP-2, 86 kD MMP-9 and 94 kD proMMP-9 were detected in control 
      group, and the activity of MMP-9 was stronger among them. After treatment of 
      radiation and chemotherapy, the activity of gelatinases of hemopoietic 
      microenviroment (HM) was obviously decreased, but low-dose, middle-dose and 
      high-dose salidroside could significantly increase the activities of proMMP-9 and 
      MMP-9, attenuate the activity of proMMP-2. These results suggest that salidroside 
      could promote the recovery of hematopoietic function of BM depressed anemic mice 
      by increasing the expression and activity of MMPs, releasing the cytokines from 
      ECM or cell membrane, repairing impaired microvessels of HM and promotion 
      proliferation, migration and differentiation of HSCs.
FAU - Zhang, Xinsheng
AU  - Zhang X
AD  - Department of Histology, Embryology and Neurobiology, West China School of Basic 
      Medicine and Forensic Medicine, Sichuan University, Chengdu 610041, China.
FAU - Zhu, Bide
AU  - Zhu B
FAU - Jin, Shenrui
AU  - Jin S
FAU - Yan, Suchun
AU  - Yan S
FAU - Chen, Zhiwei
AU  - Chen Z
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = 
      Shengwu yixue gongchengxue zazhi
JID - 9426398
RN  - 0 (Glucosides)
RN  - 0 (Phenols)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.24 (Mmp2 protein, mouse)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.35 (Mmp9 protein, mouse)
RN  - M983H6N1S9 (rhodioloside)
SB  - IM
MH  - Anemia, Aplastic/blood/*enzymology
MH  - Animals
MH  - Bone Marrow/enzymology
MH  - Glucosides/*pharmacology
MH  - Hematopoiesis/*drug effects
MH  - Male
MH  - Matrix Metalloproteinase 2/biosynthesis/genetics/*metabolism
MH  - Matrix Metalloproteinase 9/biosynthesis/genetics/*metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phenols/*pharmacology
EDAT- 2007/01/19 09:00
MHDA- 2009/05/21 09:00
CRDT- 2007/01/19 09:00
PHST- 2007/01/19 09:00 [pubmed]
PHST- 2009/05/21 09:00 [medline]
PHST- 2007/01/19 09:00 [entrez]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Dec;23(6):1314-9.