PMID- 17229285
OWN - NLM
STAT- MEDLINE
DCOM- 20070629
LR  - 20181113
IS  - 0021-8782 (Print)
IS  - 1469-7580 (Electronic)
IS  - 0021-8782 (Linking)
VI  - 210
IP  - 1
DP  - 2007 Jan
TI  - Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar and 
      Salmo trutta.
PG  - 78-88
AB  - Neurotrophins (NTs) and their signal transducing Trk receptors play a critical 
      role in the development and maintenance of specific neuronal populations in the 
      nervous system of higher vertebrates. They are responsible for the innervation of 
      the inner ear cochlear and vestibular sensory epithelia. Neurotrophins and Trks 
      are also present in teleosts but their distribution in the inner ear is unknown. 
      Thus, in the present study, we used Western-blot analysis and 
      immunohistochemistry to investigate the expression and cell localization of both 
      NTs and Trk receptors in the inner ear of alevins of Salmo salar and Salmo 
      trutta. Western-blot analysis revealed the occurrence of brain-derived 
      neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), but not nerve growth factor 
      (NGF), as well as all three Trk receptors, i.e. TrkA, TrkB and TrkC, the 
      estimated molecular weights of which were similar to those expected for mammals. 
      Specific immunoreactivity for neurotrophins was detected mainly in the sensory 
      epithelia. In particular, BDNF immunoreactivity was found in the maculae of the 
      utricle and saccule, whereas NT-3 immunoreactivity was present in the sensory 
      epithelium of the cristae ampullaris. As a rule the sensory epithelia of the 
      inner ear lacked immunoreactivity for Trks, thus excluding possible mechanisms of 
      autocrinia and/or paracrinia. By contrast, overlapping subpopulations of neurons 
      in the statoacoustic ganglion expressed TrkA (about 15%), TrkB (about 65%) and 
      TrkC (about 45%). The present results demonstrate that, as in mammals and birds, 
      the inner ear of teleosts expresses the components of the neurotrophin-Trk 
      system, but their roles remain to be elucidated.
FAU - Catania, S
AU  - Catania S
AD  - Dipartimento di Morfologia, Biochimica, Fisiologia e Produzione Animale, 
      Universita di Messina, Italy.
FAU - Germana, A
AU  - Germana A
FAU - Cabo, R
AU  - Cabo R
FAU - Ochoa-Erena, F J
AU  - Ochoa-Erena FJ
FAU - Guerrera, M C
AU  - Guerrera MC
FAU - Hannestad, J
AU  - Hannestad J
FAU - Represa, J
AU  - Represa J
FAU - Vega, J A
AU  - Vega JA
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Anat
JT  - Journal of anatomy
JID - 0137162
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Animals
MH  - Blotting, Western/methods
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Ear, Inner/*chemistry/innervation
MH  - Immunohistochemistry
MH  - Neurotrophin 3/*analysis
MH  - Receptor, trkA/analysis
MH  - Receptor, trkB/analysis
MH  - Receptor, trkC/analysis
MH  - Receptors, Nerve Growth Factor/*analysis
MH  - Salmo salar/metabolism
MH  - Salmon/*metabolism
PMC - PMC2100255
EDAT- 2007/01/19 09:00
MHDA- 2007/06/30 09:00
PMCR- 2009/01/01
CRDT- 2007/01/19 09:00
PHST- 2007/01/19 09:00 [pubmed]
PHST- 2007/06/30 09:00 [medline]
PHST- 2007/01/19 09:00 [entrez]
PHST- 2009/01/01 00:00 [pmc-release]
AID - JOA673 [pii]
AID - 10.1111/j.1469-7580.2006.00673.x [doi]
PST - ppublish
SO  - J Anat. 2007 Jan;210(1):78-88. doi: 10.1111/j.1469-7580.2006.00673.x.