PMID- 17229588
OWN - NLM
STAT- MEDLINE
DCOM- 20070514
LR  - 20131121
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 628
IP  - 2
DP  - 2007 Apr 2
TI  - Association of cooking oil fumes exposure with lung cancer: involvement of 
      inhibitor of apoptosis proteins in cell survival and proliferation in vitro.
PG  - 107-16
AB  - Cooking oil fumes (COF) have been shown to be associated with lung cancer 
      incidence in Chinese women. Our recent report indicates that inhibitor of 
      apoptosis protein 2 (IAP2) induced by COF may contribute to the survival and 
      proliferation of A549 lung cancer cells. In this study, to further verify whether 
      other antiapoptosis proteins including IAP1, X-linked IAP (XIAP), and survivin, 
      were linked with lung cancer cell survival and proliferation, these IAPs 
      expressions in A549 cells after treatment with COF and its two major components, 
      benzo[a]pyrene (BaP) and 2,4-decadienal (2,4-DDE) were evaluated by Western 
      blotting. Our data showed that IAP2 was significantly induced by COF, BaP, and 
      2,4-DDE, but XIAP was decreased by COF and 2,4-DDE, but not by BaP. Even though 
      different effects of COF and 2,4-DDE on IAP2 and XIAP protein expressions were 
      observed, the caspase-3 expression was diminished by COF and 2,4-DDE. In 
      addition, induction of IAP2 and phosphorylated Akt proteins by COF and 2,4-DDE 
      were simultaneously abolished by LY294002. Flow cytometry and terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) analysis 
      showed that the proportion of A549 cells at the S-phase was increased 
      significantly after treatment with COF or 2,4-DDE. The cell proliferation induced 
      by COF is associated with the attenuation of p21(Cip/Waf1) expression. Therefore, 
      increases of IAP1, IAP2, survivin, and cyclin D1 expressions and decreases of 
      XIAP, caspase-3, and p21 expressions might partly contribute to the survival and 
      proliferation of lung cancer cells after exposure to 2,4-DDE and COF. In 
      conclusion, the lung cancer cell growth promoted by COF might support previous 
      epidemiological reports indicating that exposure of COF was associated with lung 
      cancer development among Chinese women.
FAU - Hung, Huey-Shan
AU  - Hung HS
AD  - Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
FAU - Wu, Wen-Jun
AU  - Wu WJ
FAU - Cheng, Ya-Wen
AU  - Cheng YW
FAU - Wu, Tsu-Chin
AU  - Wu TC
FAU - Chang, Kee-Lung
AU  - Chang KL
FAU - Lee, Huei
AU  - Lee H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061222
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Aldehydes)
RN  - 0 (Carcinogens)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Smoke)
RN  - 2363-88-4 (2,4-decadienal)
RN  - 3417WMA06D (Benzo(a)pyrene)
SB  - IM
MH  - Air Pollution, Indoor/adverse effects
MH  - Aldehydes/toxicity
MH  - Benzo(a)pyrene/toxicity
MH  - Carcinogens/toxicity
MH  - *Cell Proliferation
MH  - *Cell Survival
MH  - Cooking
MH  - Dietary Fats, Unsaturated/*adverse effects
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins/genetics/*physiology
MH  - Lung Neoplasms/*etiology/genetics/pathology
MH  - Smoke/*adverse effects
MH  - Tumor Cells, Cultured
EDAT- 2007/01/19 09:00
MHDA- 2007/05/15 09:00
CRDT- 2007/01/19 09:00
PHST- 2006/01/10 00:00 [received]
PHST- 2006/12/12 00:00 [revised]
PHST- 2006/12/14 00:00 [accepted]
PHST- 2007/01/19 09:00 [pubmed]
PHST- 2007/05/15 09:00 [medline]
PHST- 2007/01/19 09:00 [entrez]
AID - S1383-5718(06)00441-4 [pii]
AID - 10.1016/j.mrgentox.2006.12.005 [doi]
PST - ppublish
SO  - Mutat Res. 2007 Apr 2;628(2):107-16. doi: 10.1016/j.mrgentox.2006.12.005. Epub 
      2006 Dec 22.