PMID- 17230227
OWN - NLM
STAT- MEDLINE
DCOM- 20070413
LR  - 20191210
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 21
IP  - 3
DP  - 2007 Mar
TI  - Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin 
      partners in B-cell lymphomas.
PG  - 515-23
AB  - Chromosomal translocations joining the immunoglobulin (IG) and MYC genes have 
      been extensively reported in Burkitt's and non-Burkitt's lymphomas but data 
      concerning MYC rearrangements with non-IG partners are scarce. In this study, 
      8q24 breakpoints from 17 B-cell lymphomas involving non-IG loci were mapped by 
      fluorescence in situ hybridization (FISH). In seven cases the breakpoint was 
      inside a small region encompassing MYC: in one t(7;8)(p12;q24) and two 
      t(3;8)(q27;q24), it was telomeric to MYC whereas in four cases, one 
      t(2;8)(p15;q24) and three t(8;9)(q24;p13) it was located in a 85 kb region 
      encompassing MYC. In these seven cases, partner regions identified by FISH 
      contained genes known to be involved in lymphomagenesis, namely BCL6, BCL11A, 
      PAX5 and IKAROS. Breakpoints were cloned in two t(8;9)(q24;p13), 2.5 and 7 kb 
      downstream from MYC and several hundred kb 5' to PAX5 on chromosome 9, joining 
      MYC to ZCCHC7 and to ZBTB5 exon 2, two genes encoding zinc-finger proteins. In 
      these seven cases, MYC expression measured by quantitative reverse 
      transcription-polymerase chain reaction (RT-PCR) was significantly higher when 
      compared to that of patients without 8q24 rearrangement (P=0.006). These results 
      suggest that these rearrangements are the consequence of a non-random process 
      targeting MYC together with non-IG genes involved in lymphocyte differentiation 
      and lymphoma progression.
FAU - Bertrand, P
AU  - Bertrand P
AD  - Groupe d'Etude des Proliferations Lymphoides, Centre Henri Becquerel, INSERM 
      U614, IFRMP23, Rouen, France. pbertrand@rouen.fnclcc.fr
FAU - Bastard, C
AU  - Bastard C
FAU - Maingonnat, C
AU  - Maingonnat C
FAU - Jardin, F
AU  - Jardin F
FAU - Maisonneuve, C
AU  - Maisonneuve C
FAU - Courel, M-N
AU  - Courel MN
FAU - Ruminy, P
AU  - Ruminy P
FAU - Picquenot, J-M
AU  - Picquenot JM
FAU - Tilly, H
AU  - Tilly H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070118
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (BCL11A protein, human)
RN  - 0 (BCL6 protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (IKZF1 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PAX5 Transcription Factor)
RN  - 0 (PAX5 protein, human)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Repressor Proteins)
RN  - 148971-36-2 (Ikaros Transcription Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Base Sequence
MH  - Burkitt Lymphoma/genetics
MH  - Carrier Proteins/genetics
MH  - Cell Transformation, Neoplastic/genetics
MH  - *Chromosome Breakage
MH  - Chromosomes, Human, Pair 2/genetics/ultrastructure
MH  - Chromosomes, Human, Pair 3/genetics/ultrastructure
MH  - Chromosomes, Human, Pair 7/genetics/ultrastructure
MH  - Chromosomes, Human, Pair 8/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 9/genetics/ultrastructure
MH  - DNA-Binding Proteins/genetics
MH  - Female
MH  - *Genes, myc
MH  - Humans
MH  - Ikaros Transcription Factor/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphoma, B-Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/genetics
MH  - PAX5 Transcription Factor/genetics
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Repressor Proteins
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Translocation, Genetic/*genetics
EDAT- 2007/01/19 09:00
MHDA- 2007/04/17 09:00
CRDT- 2007/01/19 09:00
PHST- 2007/01/19 09:00 [pubmed]
PHST- 2007/04/17 09:00 [medline]
PHST- 2007/01/19 09:00 [entrez]
AID - 2404529 [pii]
AID - 10.1038/sj.leu.2404529 [doi]
PST - ppublish
SO  - Leukemia. 2007 Mar;21(3):515-23. doi: 10.1038/sj.leu.2404529. Epub 2007 Jan 18.