PMID- 17230552
OWN - NLM
STAT- MEDLINE
DCOM- 20070417
LR  - 20131121
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 61
IP  - 4
DP  - 2007 Apr
TI  - Waved-1 mutant mice are hypersensitive to the locomotor actions of cocaine.
PG  - 259-62
AB  - Transforming growth factor-alpha (TGFalpha) is a well-known regulator of many 
      developmental processes, and is expressed heavily in basal forebrain and striatal 
      regions. When TGFalpha is reduced in Waved-1 (Wa-1) mutant mice, brain anatomy, 
      biogenic amines, stress response, and behavior are normal prior to, but altered 
      following puberty. As an initial screen for possible alterations in nigrostriatal 
      and mesolimbic dopamine (DA) systems, we tested adult Wa-1 mutant mice in an open 
      field, following acute injection with cocaine (15 mg/kg). Wa-1 mice exhibited 
      significantly greater ambulatory distance, number of ambulatory episodes, and 
      cocaine-induced motor stereotypies than do controls. These data indicate that 
      adult Wa-1 mice are hypersensitive to the locomotor effects of cocaine and 
      provide a new potential link between neurodevelopmental processes and adult 
      psychostimulant responsiveness.
FAU - Stanwood, Gregg D
AU  - Stanwood GD
AD  - Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt 
      University School of Medicine, Nashville, Tennessee 37232, USA. 
      gregg.stanwood@vanderbilt.edu
FAU - Levitt, Pat
AU  - Levitt P
LA  - eng
GR  - DA11165/DA/NIDA NIH HHS/United States
GR  - P30HD15052/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Wiskott-Aldrich Syndrome Protein Family)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Cocaine/*pharmacology
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Motor Activity/*drug effects
MH  - Stereotyped Behavior/drug effects
MH  - Wiskott-Aldrich Syndrome Protein Family/*genetics
EDAT- 2007/01/19 09:00
MHDA- 2007/04/18 09:00
CRDT- 2007/01/19 09:00
PHST- 2007/01/19 09:00 [pubmed]
PHST- 2007/04/18 09:00 [medline]
PHST- 2007/01/19 09:00 [entrez]
AID - 10.1002/syn.20364 [doi]
PST - ppublish
SO  - Synapse. 2007 Apr;61(4):259-62. doi: 10.1002/syn.20364.