PMID- 17233538
OWN - NLM
STAT- MEDLINE
DCOM- 20070228
LR  - 20181201
IS  - 1530-9932 (Electronic)
IS  - 1530-9932 (Linking)
VI  - 7
IP  - 4
DP  - 2006 Oct 13
TI  - The effect of drug concentration and curing time on processing and properties of 
      calcium alginate beads containing metronidazole by response surface methodology.
PG  - 86
AB  - The purpose of present research work was to prepare calcium alginate beads 
      containing water-soluble drug metronidazole using 3(2) factorial design, with 
      drug concentration and curing time as variables. Curing time was kept as low as 
      possible to improve entrapment with increasing drug concentration. Mostly the 
      drugs which had been encapsulated were water insoluble to facilitate drug 
      encapsulation; a characteristic drug release as whole process is aqueous based. 
      Entrapment efficiency was in the range of 81% to 96% wt/wt, which decreased with 
      decrease in polymer concentration and increase in curing time. The beads were 
      spherical with size range between 1.4 and 1.9 mm. Scanning electron microscope 
      (SEM) photomicrographs revealed increase in the leaching of drug crystals with 
      increased curing time and high drug concentrations. In acidic environment, the 
      swelling ratio was 200% in 30 minutes, but in basic medium, it increased to a 
      maximum of 1400% within 120 minutes. In acidic medium, the swelling and drug 
      release properties were influenced by drug solubility, whereas in phosphate 
      buffer these properties were governed by the gelling of polymer and exhibited 
      curvilinear and quadratic functions of both the variables, respectively.
FAU - Patel, Yagnesh L
AU  - Patel YL
AD  - Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed 
      University, Erandwane, Pune-411038, Maharashtra State, India.
FAU - Sher, Praveen
AU  - Sher P
FAU - Pawar, Atmaram P
AU  - Pawar AP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061013
PL  - United States
TA  - AAPS PharmSciTech
JT  - AAPS PharmSciTech
JID - 100960111
RN  - 0 (Alginates)
RN  - 0 (Capsules)
RN  - 0 (Drug Carriers)
RN  - 0 (Hexuronic Acids)
RN  - 140QMO216E (Metronidazole)
RN  - 8A5D83Q4RW (Glucuronic Acid)
SB  - IM
MH  - Alginates/*chemistry
MH  - Capsules/*chemistry
MH  - Diffusion
MH  - Drug Carriers/*chemistry
MH  - Drug Compounding/*methods
MH  - Glucuronic Acid/chemistry
MH  - Hardness
MH  - Hardness Tests
MH  - Hexuronic Acids/chemistry
MH  - Materials Testing
MH  - Metronidazole/administration & dosage/*chemistry
MH  - Microspheres
MH  - Solubility
MH  - Surface Properties
MH  - Time Factors
EDAT- 2007/01/20 09:00
MHDA- 2007/03/01 09:00
CRDT- 2007/01/20 09:00
PHST- 2007/01/20 09:00 [pubmed]
PHST- 2007/03/01 09:00 [medline]
PHST- 2007/01/20 09:00 [entrez]
AID - 10.1208/pt070486 [doi]
PST - epublish
SO  - AAPS PharmSciTech. 2006 Oct 13;7(4):86. doi: 10.1208/pt070486.