PMID- 17234645
OWN - NLM
STAT- MEDLINE
DCOM- 20070730
LR  - 20121115
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 96
IP  - 2
DP  - 2007 Apr
TI  - The effects of dose, route, and repeated dosing on the disposition and kinetics 
      of tetrabromobisphenol A in male F-344 rats.
PG  - 237-45
AB  - Studies were conducted to characterize the metabolic and dispositional fate of 
      (14)C-tetrabromobisphenol A (TBBPA)-a commonly used brominated flame retardant, 
      in male Fischer-344 rats. The percent of dose eliminated as total radioactivity 
      in feces at 72 h following three different single oral doses (2, 20, or 200 
      mg/kg) of (14)C-TBBPA was 90% or greater for all doses. Most of the dose was 
      eliminated in the first 24 h. At 72 h after administration of the highest dose, 
      the amounts of (14)C found in the tissues were minimal (0.2-0.9%). With repeated 
      daily oral doses (20 mg/kg) for 5 or 10 days, the cumulative percent dose 
      eliminated in the feces was 85.1+/-2.8 and 97.9+/-1.1, respectively. In all 
      studies radioactivity recovered in urine was minimal, <2%. Repeated dosing did 
      not lead to retention in tissues. Following iv administration, feces was also the 
      major route of elimination. Following iv administration of TBBPA, the radiolabel 
      found in the blood decreased rapidly and could be described by a biexponential 
      equation, consistent with a two-compartment model. The key calculated kinetic 
      parameters are terminal elimination half-life (t(1/2)beta)=82 min; area under the 
      blood concentration-time curve from time 0 to infinity (AUC)=1440 mug x min/ml; 
      and apparent clearance (CL)=2.44 ml/min. Although readily absorbed from the gut, 
      systemic bioavailability of TBBPA is low (<2%). It is extensively extracted and 
      metabolized by the liver and the metabolites (glucuronides) exported into the 
      bile. About 50% of an oral dose (20 mg/kg) was found in the bile within 2 h. This 
      extensive extraction and metabolism by the liver greatly limits exposure of 
      internal tissues to TBBPA following oral exposures.
FAU - Kuester, Robert K
AU  - Kuester RK
AD  - Department of Pharmacology, College of Medicine, The University of Arizona, 
      Tucson, Arizona 85724-5050, USA.
FAU - Solyom, Aniko M
AU  - Solyom AM
FAU - Rodriguez, Veronica P
AU  - Rodriguez VP
FAU - Sipes, I Glenn
AU  - Sipes IG
LA  - eng
GR  - CA023074/CA/NCI NIH HHS/United States
GR  - N01-ES-45529/ES/NIEHS NIH HHS/United States
GR  - P30-ES 06694/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070118
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Flame Retardants)
RN  - 0 (Polybrominated Biphenyls)
RN  - FQI02RFC3A (tetrabromobisphenol A)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Area Under Curve
MH  - Bile/metabolism
MH  - Biological Availability
MH  - Carbon Radioisotopes
MH  - Chromatography, High Pressure Liquid/methods
MH  - Dose-Response Relationship, Drug
MH  - Feces/chemistry
MH  - Flame Retardants/administration & dosage/pharmacokinetics
MH  - Half-Life
MH  - Injections, Intravenous
MH  - *Intestinal Absorption
MH  - Intubation, Gastrointestinal
MH  - Kinetics
MH  - Male
MH  - Polybrominated Biphenyls/administration & dosage/blood/*pharmacokinetics
MH  - Rats
MH  - Rats, Inbred F344
MH  - Tandem Mass Spectrometry/methods
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 2007/01/20 09:00
MHDA- 2007/07/31 09:00
CRDT- 2007/01/20 09:00
PHST- 2007/01/20 09:00 [pubmed]
PHST- 2007/07/31 09:00 [medline]
PHST- 2007/01/20 09:00 [entrez]
AID - kfm006 [pii]
AID - 10.1093/toxsci/kfm006 [doi]
PST - ppublish
SO  - Toxicol Sci. 2007 Apr;96(2):237-45. doi: 10.1093/toxsci/kfm006. Epub 2007 Jan 18.