PMID- 1723797
OWN - NLM
STAT- MEDLINE
DCOM- 19920319
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 39
IP  - 3
DP  - 1991 Jul
TI  - Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat 
      caudate.
PG  - 619-23
AB  - Extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), 
      homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and serotonin (5-HT) 
      were assayed in the caudate of freely moving rats using microdialysis and high 
      performance liquid chromatography with electrochemical detection (HPLC-EC) to 
      detect changes in their release. Dialysates were assayed at 20-minute intervals 
      for four hours after an intraperitoneal (IP) injection of MDMA (10 mg/kg). In a 
      separate study to determine MDMA effects on total caudate levels of the above 
      neurochemicals, animals were injected IP with MDMA (10 mg/kg) and then sacrificed 
      at 20, 60, 120 and 180 minutes after treatment. Brains were quickly removed, and 
      caudate nuclei were dissected for neurochemical analysis using HPLC-EC. MDMA 
      elicited an amphetamine-like increase in DA release, followed by an increase in 
      DA content. DOPAC and HVA were both reduced in homogenate. 5-HT release was also 
      increased, followed by a drop in caudate homogenate levels by three hours. DA 
      extracellular content was 686% of control at 80 minutes; caudate homogenate 
      levels were 122% at 120 minutes. 5-HT extracellular release was 123% at 20 
      minutes, then decreased thereafter. It is concluded that the acute effect of MDMA 
      on caudate is at least as great on the DA as it is on the 5-HT system.
FAU - Gough, B
AU  - Gough B
AD  - Division of Reproductive and Developmental Toxicology National Center for 
      Toxicological Research, Jefferson, AR 72079.
FAU - Ali, S F
AU  - Ali SF
FAU - Slikker, W Jr
AU  - Slikker W Jr
FAU - Holson, R R
AU  - Holson RR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Biogenic Monoamines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Biogenic Monoamines/*metabolism
MH  - Caudate Nucleus/drug effects/*metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Dialysis
MH  - Dopamine/metabolism
MH  - Electrochemistry
MH  - Female
MH  - Homovanillic Acid/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - In Vitro Techniques
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/metabolism
EDAT- 1991/07/11 19:15
MHDA- 2001/03/28 10:01
CRDT- 1991/07/11 19:15
PHST- 1991/07/11 19:15 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1991/07/11 19:15 [entrez]
AID - 0091-3057(91)90137-Q [pii]
AID - 10.1016/0091-3057(91)90137-q [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1991 Jul;39(3):619-23. doi: 
      10.1016/0091-3057(91)90137-q.