PMID- 1723801
OWN - NLM
STAT- MEDLINE
DCOM- 19920319
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 39
IP  - 3
DP  - 1991 Jul
TI  - The neurochemical and stimulatory effects of putative metabolites of 
      3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats.
PG  - 787-90
AB  - Rats were injected SC with a dose of 10 mg/kg (as base) of 
      3,4-methylenedioxyamphetamine (MDA), or 3,4-methylenedioxymethamphetamine (MDMA), 
      4-hydroxy-3-methoxyamphetamine, alpha-methyldopamine and 
      alpha-methylnorepinephrine, metabolites of MDA, and alpha-methylepinephrine, a 
      putative metabolite of MDMA, twice daily for either 5 or 7 consecutive doses. The 
      rats were killed 24 h after the last injection and monoamines in discrete brain 
      regions were assayed. MDA, MDMA, 4-hydroxy-3-methoxyamphetamine and 
      alpha-methyldopamine, but not alpha-methylepinephrine, decreased the 
      concentration of serotonin (5-HT) in the frontal cortex. MDA and MDMA, but not 
      4-hydroxy-3-methoxyamphetamine, alpha-methyldopamine and alpha-methylepinephrine, 
      also decreased the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in the 
      frontal cortexes. In stimulatory studies, MDA and MDMA, but not their metabolites 
      except alpha-methylepinephrine, which increased activity at 15 and 30 min, 
      increased locomotor activity from 15 to 180 min following the drug 
      administration.
FAU - Yeh, S Y
AU  - Yeh SY
AD  - National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.
FAU - Hsu, F L
AU  - Hsu FL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Central Nervous System Stimulants)
RN  - 10329-60-9 (alpha-methylepinephrine)
RN  - 13026-44-3 (3-O-methyl-alpha-methyldopamine)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - 555-64-6 (alpha-methyldopamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - R7339QLN1C (Deoxyepinephrine)
RN  - R81X549E70 (Nordefrin)
RN  - VTD58H1Z2X (Dopamine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/metabolism/*pharmacology
MH  - Animals
MH  - Brain Chemistry/*drug effects
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Deoxyepinephrine/analogs & derivatives/pharmacology
MH  - Dopamine/analogs & derivatives/pharmacology
MH  - Epinephrine/analogs & derivatives/pharmacology
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Nordefrin/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/metabolism
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - 0091-3057(91)90165-X [pii]
AID - 10.1016/0091-3057(91)90165-x [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1991 Jul;39(3):787-90. doi: 
      10.1016/0091-3057(91)90165-x.