PMID- 17238032
OWN - NLM
STAT- MEDLINE
DCOM- 20070510
LR  - 20181113
IS  - 0944-1174 (Print)
IS  - 0944-1174 (Linking)
VI  - 42 Suppl 17
DP  - 2007 Jan
TI  - Can measurement of chemokines become useful biological and functional markers of 
      early-stage chronic pancreatitis?
PG  - 72-7
AB  - Chronic pancreatitis, an irreversible inflammatory disease of the pancreas, is 
      characterized by chronic inflammatory cell infiltration, acinar cell 
      degeneration, and development of fibrosis, which lead to impairment of pancreatic 
      exocrine and endocrine function. Despite marked progress in diagnostic tools and, 
      especially, imaging methods, no consensus has been reached on nomenclature in 
      diagnosis of chronic pancreatitis. A major problem is that no reliable diagnostic 
      test exists for early-stage chronic pancreatitis. The identification of the 
      chemokine system, however, has elucidated the molecular mechanisms of the 
      inflammation contributing to the development of fibrosis in the progression of 
      chronic pancreatitis. Inflammatory chemokines are obviously associated with the 
      chemoattraction of leukocytes in early-stage chronic pancreatitis. Migration of 
      monocytes into the pancreas is one of the earliest events in the formation of 
      pancreatic fibrosis. In particular, monocyte chemoattractant protein-1 (MCP-1) is 
      considered to be a prefibrogenic factor in the progression of chronic 
      pancreatitis. Lately, fractalkine/CX3CL1 is reported to be a membrane-spanning 
      adhesion molecule that can be cleaved from the cell surface to produce a soluble 
      chemoattractant. Our preliminary study showed that serum soluble fractalkine did 
      not correlate with MCP-1 or transforming growth factor beta1 and increased in 
      patients with early-stage chronic pancreatitis. Furthermore, serum soluble 
      fractalkine did not correlate with pancreatic-specific enzymes, such as 
      pancreatic amylase and lipase, and N-benzoyl-L-tyrosyl-p-aminobenzoic acid test 
      results. Therefore, measurement of soluble fractalkine in human serum may be 
      useful as a diagnostic marker of early-stage chronic pancreatitis, and should be 
      considered in future studies, including detailed investigations of soluble 
      fractalkine in patients with chronic pancreatitis.
FAU - Ito, Tetsuhide
AU  - Ito T
AD  - Pancreas Diseases Branch, Department of Medicine and Bioregulatory Science, 
      Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, 
      Higashi-ku, Fukuoka, 812-5258, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (Biomarkers)
RN  - 0 (Chemokines)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Chemokines/*metabolism
MH  - Early Diagnosis
MH  - Humans
MH  - Pancreatitis, Chronic/*diagnosis/*metabolism
RF  - 38
EDAT- 2007/01/24 09:00
MHDA- 2007/05/11 09:00
CRDT- 2007/01/24 09:00
PHST- 2007/01/24 09:00 [pubmed]
PHST- 2007/05/11 09:00 [medline]
PHST- 2007/01/24 09:00 [entrez]
AID - 10.1007/s00535-006-1929-4 [doi]
PST - ppublish
SO  - J Gastroenterol. 2007 Jan;42 Suppl 17:72-7. doi: 10.1007/s00535-006-1929-4.