PMID- 17239678
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20071115
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Linking)
VI  - 153
IP  - 2
DP  - 2007 Feb
TI  - Design and rationale for the Myocardial Stem Cell Administration After Acute 
      Myocardial Infarction (MYSTAR) Study: a multicenter, prospective, randomized, 
      single-blind trial comparing early and late intracoronary or combined 
      (percutaneous intramyocardial and intracoronary) administration of nonselected 
      autologous bone marrow cells to patients after acute myocardial infarction.
PG  - 212.e1-7
AB  - BACKGROUND: Previous data suggest that bone marrow-derived stem cells (BM-SCs) 
      decrease the infarct size and beneficially affect the postinfarction remodeling. 
      METHODS: The Myocardial Stem Cell Administration After Acute Myocardial 
      Infarction Study is a multicenter, prospective, randomized, single-blind clinical 
      trial designed to compare the early and late intracoronary or combined 
      (percutaneous intramyocardial and intracoronary) administration of BM-SCs to 
      patients after acute myocardial infarction (AMI) with reopened infarct-related 
      artery. The primary end points are the changes in resting myocardial perfusion 
      defect size and left ventricular ejection fraction (gated single photon emission 
      computed tomography [SPECT] scintigraphy) 3 months after BM-SCs therapy. The 
      secondary end points relate to evaluation of (1) the safety and feasibility of 
      the application modes, (2) the changes in left ventricular wall motion score 
      index (transthoracic echocardiography), (3) myocardial voltage and segmental wall 
      motion (NOGA mapping), (4) left ventricular end-diastolic and end-systolic 
      volumes (contrast ventriculography), and (5) the clinical symptoms (Canadian 
      Cardiovascular Society [CCS] anina score and New York Heart Association [NYHA] 
      functional class) at follow-up. Three hundred sixty patients are randomly 
      assigned into 1 of 4 groups: group A, early treatment (21-42 days after AMI) with 
      intracoronary injection; group B, early treatment with combined application; 
      group C, late treatment (3 months after AMI) with intracoronary delivery; and 
      group D, late treatment with combined administration of BM-SCs. Besides the 
      BM-SCs therapy, the standardized treatment of AMI is applied in all patients. 
      CONCLUSIONS: The Myocardial Stem Cell Administration After Acute Myocardial 
      Infarction Trial is the first randomized trial to investigate the effects of the 
      combined (intramyocardial and intracoronary) and the intracoronary mode of 
      delivery of BM-SCs therapy in the early and late periods after AMI.
FAU - Nyolczas, Noemi
AU  - Nyolczas N
AD  - Department of Cardiology, Medical University of Vienna, Vienna, Austria.
FAU - Gyongyosi, Mariann
AU  - Gyongyosi M
FAU - Beran, Gilbert
AU  - Beran G
FAU - Dettke, Markus
AU  - Dettke M
FAU - Graf, Senta
AU  - Graf S
FAU - Sochor, Heinz
AU  - Sochor H
FAU - Christ, Gunther
AU  - Christ G
FAU - Edes, Istvan
AU  - Edes I
FAU - Balogh, Laszlo
AU  - Balogh L
FAU - Krause, Korff T
AU  - Krause KT
FAU - Jaquet, Kai
AU  - Jaquet K
FAU - Kuck, Karl-Heinz
AU  - Kuck KH
FAU - Benedek, Imre
AU  - Benedek I
FAU - Hintea, Theodora
AU  - Hintea T
FAU - Kiss, Robert
AU  - Kiss R
FAU - Preda, Istvan
AU  - Preda I
FAU - Kotevski, Vladimir
AU  - Kotevski V
FAU - Pejkov, Hristo
AU  - Pejkov H
FAU - Dudek, Darius
AU  - Dudek D
FAU - Heba, Grzegorz
AU  - Heba G
FAU - Sylven, Christer
AU  - Sylven C
FAU - Charwat, Silvia
AU  - Charwat S
FAU - Jacob, Ronaldo
AU  - Jacob R
FAU - Maurer, Gerald
AU  - Maurer G
FAU - Lang, Irene
AU  - Lang I
FAU - Glogar, Dietmar
AU  - Glogar D
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
MH  - Bone Marrow Transplantation/*methods
MH  - Coronary Vessels
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Myocardial Infarction/*surgery
MH  - Myocardium
MH  - Prospective Studies
MH  - Research Design
MH  - Single-Blind Method
MH  - Time Factors
EDAT- 2007/01/24 09:00
MHDA- 2007/03/21 09:00
CRDT- 2007/01/24 09:00
PHST- 2006/05/24 00:00 [received]
PHST- 2006/10/09 00:00 [accepted]
PHST- 2007/01/24 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/01/24 09:00 [entrez]
AID - S0002-8703(06)00948-3 [pii]
AID - 10.1016/j.ahj.2006.10.027 [doi]
PST - ppublish
SO  - Am Heart J. 2007 Feb;153(2):212.e1-7. doi: 10.1016/j.ahj.2006.10.027.