PMID- 17239887
OWN - NLM
STAT- MEDLINE
DCOM- 20071207
LR  - 20071227
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 195
IP  - 1
DP  - 2007 Nov
TI  - Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with 
      atherosclerotic plaque instability--analysis in hypercholesterolemic rabbits.
PG  - 48-56
AB  - Lectin-like oxidized LDL receptor-1 (LOX-1), a cell-surface receptor for oxidized 
      LDL (Ox-LDL), has been implicated in vascular cell dysfunction related to 
      atherosclerotic plaque instability, according to cell culture experiments. In the 
      present study, we investigated the relationship between LOX-1 expression and 
      plaque instability in hypercholesterolemic rabbits by immunohistological analyses 
      in vivo. We prepared thirty series of cross sections of the thoracic aorta from 
      six myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) 
      rabbits (12-24 months), in which seventy atherosclerotic plaques were observed. 
      LOX-1, matrix metalloproteinase-9 (MMP-9), monocyte chemoattractant protein-1 
      (MCP-1) expression, apoptotic events, plaque instability index (an index of the 
      morphological destabilization of atherosclerotic plaques) and fibromuscular cap 
      thickness in each atherosclerotic plaque were determined by immunohistochemical 
      staining, TUNEL staining and Azan-Mallory staining. LOX-1 expression was 
      positively correlated with the plaque instability index and MMP-9 expression. 
      LOX-1 expression was more prominent in atherosclerotic plaques with thinner 
      fibromuscular cap (<100 microm). Furthermore, LOX-1 expression was shown in the 
      macrophage-rich lipid core area where MCP-1 expression and apoptotic events were 
      prominent. These results indicate that enhanced LOX-1 expression was associated 
      with histologically unstable atherosclerotic plaques in hypercholesterolemic 
      rabbits, suggesting the involvement of LOX-1 in the destabilization of 
      atherosclerotic plaques in vivo.
FAU - Ishino, Seigo
AU  - Ishino S
AD  - Department of Patho-functional Bioanalysis, Graduate School of Pharmaceutical 
      Sciences, Kyoto University, Japan.
FAU - Mukai, Takahiro
AU  - Mukai T
FAU - Kume, Noriaki
AU  - Kume N
FAU - Asano, Daigo
AU  - Asano D
FAU - Ogawa, Mikako
AU  - Ogawa M
FAU - Kuge, Yuji
AU  - Kuge Y
FAU - Minami, Manabu
AU  - Minami M
FAU - Kita, Toru
AU  - Kita T
FAU - Shiomi, Masashi
AU  - Shiomi M
FAU - Saji, Hideo
AU  - Saji H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070119
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Chemokine CCL2)
RN  - 0 (MCP1 protein, rabbit)
RN  - 0 (Scavenger Receptors, Class E)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/chemistry/metabolism
MH  - Aorta, Thoracic/metabolism/pathology
MH  - Apoptosis
MH  - Atherosclerosis
MH  - Chemokine CCL2/biosynthesis
MH  - *Gene Expression Regulation
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Models, Biological
MH  - Rabbits
MH  - Scavenger Receptors, Class E/*biosynthesis
EDAT- 2007/01/24 09:00
MHDA- 2007/12/08 09:00
CRDT- 2007/01/24 09:00
PHST- 2006/03/22 00:00 [received]
PHST- 2006/10/30 00:00 [revised]
PHST- 2006/11/21 00:00 [accepted]
PHST- 2007/01/24 09:00 [pubmed]
PHST- 2007/12/08 09:00 [medline]
PHST- 2007/01/24 09:00 [entrez]
AID - S0021-9150(06)00703-9 [pii]
AID - 10.1016/j.atherosclerosis.2006.11.031 [doi]
PST - ppublish
SO  - Atherosclerosis. 2007 Nov;195(1):48-56. doi: 
      10.1016/j.atherosclerosis.2006.11.031. Epub 2007 Jan 19.