PMID- 17240051
OWN - NLM
STAT- MEDLINE
DCOM- 20070628
LR  - 20220410
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 251
IP  - 1
DP  - 2007 Jun 18
TI  - Intrahepatic interleukin-8 production during disease progression of chronic 
      hepatitis C.
PG  - 36-42
AB  - The current study was designed to investigate the contribution of chemokines to 
      the pathogenesis of chronic hepatitis C and hepatocellular carcinoma (HCC) by 
      measuring the production of IL-8, monocyte chemoattractant protein-1 (MCP-1) and 
      macrophage inflammatory protein-1 alpha (MIP-1alpha). A solid-phase sandwich 
      enzyme-linked immunosorbent assay (ELISA) was established to quantitate serum 
      concentrations of the chemokines. Expression of chemokines in liver tissues was 
      evaluated immunohistochemically using specific monoclonal antibodies. As the 
      severity of chronic hepatitis escalated, serum IL-8 levels increased 
      progressively. Moreover, in the hepatocellular carcinoma (HCC) patients, IL-8 
      concentrations were positively correlated with the macroscopic staging of HCC, 
      and inversely correlated with the duration of the survival periods. The results 
      demonstrate that IL-8 production may be augmented upon the malignant 
      transformation of hepatocytes in chronic hepatitis C.
FAU - Tachibana, Yoshiya
AU  - Tachibana Y
AD  - Department of Gastroenterology, Graduate School of Medical Science, Kanazawa 
      University, Kanazawa 920-8641, Ishikawa, Japan.
FAU - Nakamoto, Yasunari
AU  - Nakamoto Y
FAU - Mukaida, Naofumi
AU  - Mukaida N
FAU - Kaneko, Shuichi
AU  - Kaneko S
LA  - eng
PT  - Journal Article
DEP - 20070119
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL3 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokines, CC)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/blood/pathology
MH  - Chemokine CCL2/blood
MH  - Chemokine CCL3
MH  - Chemokines, CC/blood
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Hepatitis C, Chronic/blood/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukin-8/biosynthesis/*blood
MH  - Liver/metabolism/*pathology/virology
MH  - Liver Neoplasms/blood/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Survival Analysis
EDAT- 2007/01/24 09:00
MHDA- 2007/06/29 09:00
CRDT- 2007/01/24 09:00
PHST- 2006/08/01 00:00 [received]
PHST- 2006/10/24 00:00 [revised]
PHST- 2006/10/26 00:00 [accepted]
PHST- 2007/01/24 09:00 [pubmed]
PHST- 2007/06/29 09:00 [medline]
PHST- 2007/01/24 09:00 [entrez]
AID - S0304-3835(06)00581-7 [pii]
AID - 10.1016/j.canlet.2006.10.028 [doi]
PST - ppublish
SO  - Cancer Lett. 2007 Jun 18;251(1):36-42. doi: 10.1016/j.canlet.2006.10.028. Epub 
      2007 Jan 19.