PMID- 17240165
OWN - NLM
STAT- MEDLINE
DCOM- 20070416
LR  - 20220309
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 35
IP  - 1
DP  - 2007 Mar
TI  - Social cognition and frontal lobe pathology in schizophrenia: a voxel-based 
      morphometric study.
PG  - 292-8
AB  - Impaired social cognition in schizophrenia is considered as the core contributor 
      in the poor psychosocial functioning of schizophrenic patients. In this study, in 
      order to better understand the neurobiological processes underlying social 
      dysfunction in schizophrenia, we investigated regional structural brain 
      abnormalities and emotion-attribution abilities in these patients. Twenty 
      schizophrenic patients and 20 group-matched healthy comparison participants 
      underwent magnetic resonance imaging (MRI) and were examined for 
      emotion-attribution abilities by using the Perception of Affect Task (PAT). 
      Voxel-based morphometry (VBM) was applied to investigate regional brain 
      structural alterations. Relative to the healthy participants, the schizophrenic 
      patients exhibited reduced gray matter concentrations in the left superior 
      temporal gyrus, the medial prefrontal cortex (MPFC), right anterior cingulate 
      gyrus, bilateral ventrolateral prefrontal cortex, and right insula. The 
      schizophrenic patients performed poorly on emotion-attribution tasks. 
      Importantly, poor performance on emotion attribution to protagonists in social 
      situations was found to be associated with reductions in gray matter in the MPFC 
      of the patient group. This preliminary result suggests that in schizophrenia, 
      difficulties in understanding the emotional experiences of others are possible 
      manifestations of structural abnormalities in the MPFC. This study provides the 
      neurobiological correlates of social dysfunction in schizophrenia and links 
      structural abnormalities with impaired social cognitive abilities.
FAU - Yamada, Makiko
AU  - Yamada M
AD  - Department of Neuropsychiatry, Graduate School of Medicine, Kyoto University, 54 
      Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. yamada@kuhp.kyoto-u.ac.jp 
      <yamada@kuhp.kyoto-u.ac.jp>
FAU - Hirao, Kazuyuki
AU  - Hirao K
FAU - Namiki, Chihiro
AU  - Namiki C
FAU - Hanakawa, Takashi
AU  - Hanakawa T
FAU - Fukuyama, Hidenao
AU  - Fukuyama H
FAU - Hayashi, Takuji
AU  - Hayashi T
FAU - Murai, Toshiya
AU  - Murai T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070119
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Cognition/*physiology
MH  - Emotions/physiology
MH  - Face
MH  - Female
MH  - Frontal Lobe/*pathology
MH  - Humans
MH  - Intelligence Tests
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuropsychological Tests
MH  - Psychomotor Performance/physiology
MH  - Recognition, Psychology/physiology
MH  - Schizophrenia/*pathology
MH  - *Schizophrenic Psychology
MH  - *Social Behavior
EDAT- 2007/01/24 09:00
MHDA- 2007/04/17 09:00
CRDT- 2007/01/24 09:00
PHST- 2006/07/26 00:00 [received]
PHST- 2006/10/18 00:00 [revised]
PHST- 2006/10/24 00:00 [accepted]
PHST- 2007/01/24 09:00 [pubmed]
PHST- 2007/04/17 09:00 [medline]
PHST- 2007/01/24 09:00 [entrez]
AID - S1053-8119(06)01071-8 [pii]
AID - 10.1016/j.neuroimage.2006.10.046 [doi]
PST - ppublish
SO  - Neuroimage. 2007 Mar;35(1):292-8. doi: 10.1016/j.neuroimage.2006.10.046. Epub 
      2007 Jan 19.