PMID- 17241316
OWN - NLM
STAT- MEDLINE
DCOM- 20070709
LR  - 20220316
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 30
IP  - 1
DP  - 2007 Jan
TI  - Changes in heart rate variability, quality of life, and activity in cardiac 
      resynchronization therapy patients: results of the HF-HRV registry.
PG  - 56-64
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) is a viable therapy in the 
      treatment of heart failure (HF). Heart rate variability (HRV) is a prognostic 
      marker of HF and mortality and is a sign of autonomic dysfunction. Acute 
      improvements in measures of HRV have been demonstrated after CRT in small 
      clinical studies. The purpose of the present study was to evaluate changes in HRV 
      and patient outcomes over time and the relationship between these changes in a 
      large generalized sample of patients who received CRT with defibrillator (CRT-D). 
      METHODS: The Heart Failure-Heart Rate Variability (HF-HRV) registry enrolled 
      1,421 patients who received a CRT-D device capable of measuring HRV. Patients 
      were followed for a 1-year period. Device diagnostics, including HRV footprint; 
      standard deviation of averaged normal R to R intervals (SDANN); and mean, 
      minimum, and maximum heart rate were measured at each visit, in addition to 
      activity log, New York Heart Association (NYHA) class, and quality of life (QOL) 
      data. RESULTS: This large sample of HF patients showed an overall improvement in 
      SDANN (69.2 +/- 25.5, 78.5 +/- 27.8, 79.4 +/- 27.2, 80.7 +/- 28.2) and HRV 
      footprint (31.5 +/- 11.8, 33.4 +/- 12.3, 34.2 +/- 12.2, 34.5 +/- 12.3) at the 2 
      week, 3 month, 6 month, and 12 month visits, respectively (both P < 0.001). There 
      were also significant changes over time in clinical status (improved QOL, 
      increased activity, and improved NYHA, all P < 0.0001), with the greatest changes 
      occurring between the 2 week and 3 month visits. CONCLUSION: In conclusion, these 
      study results demonstrate that device measured HRV parameters and patient 
      outcomes significantly improve after receipt of CRT.
FAU - Gilliam, F Roosevelt 3rd
AU  - Gilliam FR 3rd
AD  - Cardiology Associates of Northeast Arkansas, Jonesboro, AR 72401, USA. 
      rgilliam@arkheart.com
FAU - Kaplan, Andrew J
AU  - Kaplan AJ
FAU - Black, James
AU  - Black J
FAU - Chase, Kellie J
AU  - Chase KJ
FAU - Mullin, Christopher M
AU  - Mullin CM
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Aged
MH  - *Cardiac Pacing, Artificial
MH  - *Electric Countershock
MH  - Female
MH  - Heart Failure/*physiopathology/*therapy
MH  - *Heart Rate
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Registries
MH  - Treatment Outcome
EDAT- 2007/01/24 09:00
MHDA- 2007/07/10 09:00
CRDT- 2007/01/24 09:00
PHST- 2007/01/24 09:00 [pubmed]
PHST- 2007/07/10 09:00 [medline]
PHST- 2007/01/24 09:00 [entrez]
AID - PACE582 [pii]
AID - 10.1111/j.1540-8159.2007.00582.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2007 Jan;30(1):56-64. doi: 
      10.1111/j.1540-8159.2007.00582.x.