PMID- 17241828 OWN - NLM STAT- MEDLINE DCOM- 20070320 LR - 20161019 IS - 0006-3223 (Print) IS - 0006-3223 (Linking) VI - 61 IP - 3 DP - 2007 Feb 1 TI - Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder. PG - 322-9 AB - BACKGROUND: Family-based evidence for association at serotonin system genes SLC6A4, HTR1B, HTR2A, and brain-derived neurotrophic factor (BDNF) has been previously reported in obsessive-compulsive disorder (OCD). Early-onset OCD is a more familial form of the disorder. METHODS: We used the transmission-disequilibrium test of association at common polymorphisms in each of these genes in 54 parent-child trios ascertained through probands with early-onset OCD. RESULTS: No evidence for association was detected at any of the polymorphisms in the entire set of subjects. Nominally significant association was found at the HTR2A rs6311 polymorphism in subjects with tic disorder and OCD (p = .05), replicating a previous finding in Tourette syndrome and OCD. Nominally significant association was also found for the SLC6A4 HT transporter gene-linked polymorphic region (5-HTTLPR) polymorphism for female subjects (p = .03). Neither association would remain significant after statistical correction for multiple testing. Despite no individual study reporting replication, a pooled analysis of five replication studies of the SLC6A4 5-HTTLPR polymorphism supports association (p = .02). CONCLUSIONS: Low power across individual association studies in OCD may lead to a false acceptance of the null hypothesis. Accumulation of evidence from multiple studies will be necessary to evaluate the potential role for these genes in contributing to susceptibility to OCD. FAU - Dickel, Diane E AU - Dickel DE AD - Institute of Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA. FAU - Veenstra-VanderWeele, Jeremy AU - Veenstra-VanderWeele J FAU - Bivens, Nancy Chiu AU - Bivens NC FAU - Wu, Xiaolin AU - Wu X FAU - Fischer, Daniel J AU - Fischer DJ FAU - Van Etten-Lee, Michelle AU - Van Etten-Lee M FAU - Himle, Joseph A AU - Himle JA FAU - Leventhal, Bennett L AU - Leventhal BL FAU - Cook, Edwin H Jr AU - Cook EH Jr FAU - Hanna, Gregory L AU - Hanna GL LA - eng GR - K08 MH090397/MH/NIMH NIH HHS/United States GR - K02 MH01389/MH/NIMH NIH HHS/United States GR - K20 MH01065/MH/NIMH NIH HHS/United States GR - R01 MH58376/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Biol Psychiatry JT - Biological psychiatry JID - 0213264 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Receptor, Serotonin, 5-HT1B) RN - 0 (Receptor, Serotonin, 5-HT2A) RN - 0 (SLC6A4 protein, human) RN - 0 (Serotonin Plasma Membrane Transport Proteins) RN - 333DO1RDJY (Serotonin) RN - 9007-49-2 (DNA) SB - IM MH - Adolescent MH - Adult MH - Age of Onset MH - Aged MH - Aged, 80 and over MH - Brain-Derived Neurotrophic Factor/genetics MH - Child MH - Child, Preschool MH - DNA/genetics/isolation & purification MH - Female MH - Genotype MH - Humans MH - Linkage Disequilibrium/genetics MH - Male MH - Middle Aged MH - Obsessive-Compulsive Disorder/epidemiology/*genetics/*physiopathology MH - Polymorphism, Genetic/genetics MH - Polymorphism, Single Nucleotide MH - Psychiatric Status Rating Scales MH - Receptor, Serotonin, 5-HT1B/genetics MH - Receptor, Serotonin, 5-HT2A/genetics MH - Reverse Transcriptase Polymerase Chain Reaction MH - Serotonin/*genetics/*physiology MH - Serotonin Plasma Membrane Transport Proteins/genetics MH - Sex Factors MH - Tic Disorders/epidemiology MH - Tourette Syndrome/epidemiology/genetics EDAT- 2007/01/24 09:00 MHDA- 2007/03/21 09:00 CRDT- 2007/01/24 09:00 PHST- 2006/01/06 00:00 [received] PHST- 2006/08/14 00:00 [revised] PHST- 2006/09/19 00:00 [accepted] PHST- 2007/01/24 09:00 [pubmed] PHST- 2007/03/21 09:00 [medline] PHST- 2007/01/24 09:00 [entrez] AID - S0006-3223(06)01217-0 [pii] AID - 10.1016/j.biopsych.2006.09.030 [doi] PST - ppublish SO - Biol Psychiatry. 2007 Feb 1;61(3):322-9. doi: 10.1016/j.biopsych.2006.09.030.