PMID- 1724461
OWN - NLM
STAT- MEDLINE
DCOM- 19920406
LR  - 20190918
IS  - 0742-3098 (Print)
IS  - 0742-3098 (Linking)
VI  - 11
IP  - 3-4
DP  - 1991 Oct-Nov
TI  - Pineal serotonin is resistant to depletion by serotonergic neurotoxins in rats.
PG  - 163-7
AB  - Administration of 3,4-methylenedioxymethamphetamine (MDMA) or 
      para-chloroamphetamine (pCA) to adult rats is neurotoxic to serotonin (5HT) nerve 
      terminals and cell bodies. MDMA (10 mg/kg) reduces 5HT levels in the frontal 
      cortex, medial basal hypothalamus, and striatum acutely and 17 days after a 
      series of multiple injections. The acute reductions occur within 1-2 hr after 
      injection of doses greater than 3 mg/kg. A single injection of pCA reduces 5HT 
      levels in the above mentioned brain regions as well as in the brain stem. 
      However, none of these treatments are able to alter 5HT levels in the pineal 
      gland. It appears that the pineal does not contain the 5HT reuptake system that 
      is thought to be necessary for the neurotoxicity of MDMA and pCA.
FAU - Champney, T H
AU  - Champney TH
AD  - Department of Human Anatomy, College of Medicine, Texas A&M University, College 
      Station 77843-1114.
FAU - Matthews, R T
AU  - Matthews RT
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Pineal Res
JT  - Journal of pineal research
JID - 8504412
RN  - 0 (Designer Drugs)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - 64-12-0 (p-Chloroamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Brain/drug effects
MH  - Designer Drugs/administration & dosage
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Pineal Gland/*drug effects/metabolism
MH  - Rats
MH  - Serotonin/*metabolism
MH  - p-Chloroamphetamine/*pharmacology
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
AID - 10.1111/j.1600-079x.1991.tb00473.x [doi]
PST - ppublish
SO  - J Pineal Res. 1991 Oct-Nov;11(3-4):163-7. doi: 
      10.1111/j.1600-079x.1991.tb00473.x.