PMID- 17245591
OWN - NLM
STAT- MEDLINE
DCOM- 20070712
LR  - 20071115
IS  - 0939-5555 (Print)
IS  - 0939-5555 (Linking)
VI  - 86
IP  - 5
DP  - 2007 May
TI  - Clinical and molecular cytogenetic characteristics of dic(9;20) in adult acute 
      lymphoblastic leukemia: a case report of three patients.
PG  - 347-51
AB  - Dicentric (9;20) [dic(9;20)] is a rare recurring chromosome abnormality in 
      leukemia patients. In this study, we report three adult patients with acute 
      lymphoblastic leukemia (ALL) with dic(9;20) anomaly. All three patients were 
      diagnosed as cluster of differentiation 10 (CD10) positive B cell ALL, achieved 
      complete remission after induction chemotherapy, and died of leukemia relapse 
      within 1 year after diagnosis. Specimens for chromosome analysis were prepared by 
      direct method and/or short-time culture of bone marrow cells. Karyotyping was 
      performed by R-banding technique. Dual-color fluorescence in situ hybridization 
      (FISH) was performed using chromosome 9 and chromosome 20-specific centromeric 
      probes. Karyotype analysis showed that all three patients had 
      dic(9;20)(p11-13;q11), in which the dicentric nature of the derived chromosome 
      was confirmed by interphase FISH. Dicentric (9;20)(p11-13;q11) may be 
      specifically associated with ALL, and monosomy 20 may be a pointer to dic(9;20) 
      in ALL. The prognostic significance of dic(9;20) in adult patients with ALL 
      remains to be determined.
FAU - Song, Xianmin
AU  - Song X
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai, People's Republic of China.
FAU - Gong, Shenglan
AU  - Gong S
FAU - Yang, Jianmin
AU  - Yang J
FAU - Wang, Jianmin
AU  - Wang J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20070124
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
SB  - IM
MH  - Adult
MH  - Burkitt Lymphoma/*genetics
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 20
MH  - *Chromosomes, Human, Pair 9
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Translocation, Genetic
EDAT- 2007/01/25 09:00
MHDA- 2007/07/13 09:00
CRDT- 2007/01/25 09:00
PHST- 2006/11/19 00:00 [received]
PHST- 2007/01/08 00:00 [accepted]
PHST- 2007/01/25 09:00 [pubmed]
PHST- 2007/07/13 09:00 [medline]
PHST- 2007/01/25 09:00 [entrez]
AID - 10.1007/s00277-007-0255-0 [doi]
PST - ppublish
SO  - Ann Hematol. 2007 May;86(5):347-51. doi: 10.1007/s00277-007-0255-0. Epub 2007 Jan 
      24.