PMID- 17251358
OWN - NLM
STAT- MEDLINE
DCOM- 20070703
LR  - 20131121
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 22
IP  - 4
DP  - 2007 Apr
TI  - Influence of endogenous and exogenous sex hormones on plasma brain-derived 
      neurotrophic factor.
PG  - 995-1002
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a mediator of neuronal 
      plasticity and influences learning, memory and cognitive behaviour. The aim of 
      this study is to assess plasma BDNF variations according to hormonal status. 
      METHODS: A total of 60 subjects were included: 20 fertile ovulatory women, 15 
      amenorrhoeic women and 25 postmenopausal women. Blood samples were collected 
      after overnight fasting. For 5 out of the 20 fertile women, samples were 
      collected every 2 days throughout the whole menstrual cycle. Following basal 
      evaluation, 10 out of 25 postmenopausal women were administered a hormone 
      replacement therapy (HRT) and reevaluated after 6 months of treatment. Plasma 
      BDNF concentrations were measured by enzyme-linked immunosorbent assay. In 
      fertile women, estradiol (E(2)), progesterone and gonadotrophins were also 
      assessed. RESULTS: In fertile women, luteal phase levels of plasma BDNF were 
      significantly higher than follicular phase levels (P < 0.001). BDNF increased 
      from early follicular phase up to Day 14 of the cycle, reaching a pre-ovulatory 
      peak, similar to E(2). A second rise took place during mid-luteal phase, with a 
      peak on Day 24. Amenorrhoeic subjects, as well as postmenopausal women, showed 
      significantly lower plasma BDNF levels compared with fertile females (P < 0.001). 
      BDNF was positively correlated with E(2) and progesterone and negatively 
      correlated with menopausal age. HRT restored BDNF levels to those present in 
      fertile women during the follicular phase. CONCLUSIONS: Plasma BDNF levels are 
      influenced by hormonal status. Modifications in BDNF circulating levels during 
      the menstrual cycle suggest a potential role for gonadal sex hormones (E(2) and 
      progesterone) in regulating neurotrophin expression.
FAU - Begliuomini, S
AU  - Begliuomini S
AD  - Department of Reproductive Medicine and Child Development, Division of Gynecology 
      and Obstetrics, University of Pisa, Pisa, Italy.
FAU - Casarosa, E
AU  - Casarosa E
FAU - Pluchino, N
AU  - Pluchino N
FAU - Lenzi, E
AU  - Lenzi E
FAU - Centofanti, M
AU  - Centofanti M
FAU - Freschi, L
AU  - Freschi L
FAU - Pieri, M
AU  - Pieri M
FAU - Genazzani, A D
AU  - Genazzani AD
FAU - Luisi, S
AU  - Luisi S
FAU - Genazzani, Andrea R
AU  - Genazzani AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070124
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amenorrhea/metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood/chemistry
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Estradiol/*metabolism
MH  - Female
MH  - Hormone Replacement Therapy/methods
MH  - Humans
MH  - Menstrual Cycle
MH  - Middle Aged
MH  - Ovary/*physiology
MH  - Ovulation
MH  - Postmenopause
MH  - Progesterone/*metabolism
EDAT- 2007/01/26 09:00
MHDA- 2007/07/04 09:00
CRDT- 2007/01/26 09:00
PHST- 2007/01/26 09:00 [pubmed]
PHST- 2007/07/04 09:00 [medline]
PHST- 2007/01/26 09:00 [entrez]
AID - del479 [pii]
AID - 10.1093/humrep/del479 [doi]
PST - ppublish
SO  - Hum Reprod. 2007 Apr;22(4):995-1002. doi: 10.1093/humrep/del479. Epub 2007 Jan 
      24.