PMID- 17252545
OWN - NLM
STAT- MEDLINE
DCOM- 20070601
LR  - 20220129
IS  - 0364-5134 (Print)
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 61
IP  - 3
DP  - 2007 Mar
TI  - A second major histocompatibility complex susceptibility locus for multiple 
      sclerosis.
PG  - 228-36
AB  - OBJECTIVE: Variation in the major histocompatibility complex (MHC) on chromosome 
      6p21 is known to influence susceptibility to multiple sclerosis with the 
      strongest effect originating from the HLA-DRB1 gene in the class II region. The 
      possibility that other genes in the MHC independently influence susceptibility to 
      multiple sclerosis has been suggested but remains unconfirmed. METHODS: Using a 
      combination of microsatellite, single nucleotide polymorphism, and human 
      leukocyte antigen (HLA) typing, we screened the MHC in trio families looking for 
      evidence of residual association above and beyond that attributable to the 
      established DRB1*1501 risk haplotype. We then refined this analysis by extending 
      the genotyping of classical HLA loci into independent cases and control subjects. 
      RESULTS: Screening confirmed the presence of residual association and suggested 
      that this was maximal in the region of the HLA-C gene. Extending analysis of the 
      classical loci confirmed that this residual association is partly due to allelic 
      heterogeneity at the HLA-DRB1 locus, but also reflects an independent effect from 
      the HLA-C gene. Specifically, the HLA-C*05 allele, or a variant in tight linkage 
      disequilibrium with it, appears to exert a protective effect (p = 3.3 x 10(-5)). 
      INTERPRETATION: Variation in the HLA-C gene influences susceptibility to multiple 
      sclerosis independently of any effect attributable to the nearby HLA-DRB1 gene.
FAU - Yeo, Tai Wai
AU  - Yeo TW
AD  - Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's 
      Hospital, Cambridge, United Kingdom.
FAU - De Jager, Philip L
AU  - De Jager PL
FAU - Gregory, Simon G
AU  - Gregory SG
FAU - Barcellos, Lisa F
AU  - Barcellos LF
FAU - Walton, Amie
AU  - Walton A
FAU - Goris, An
AU  - Goris A
FAU - Fenoglio, Chiara
AU  - Fenoglio C
FAU - Ban, Maria
AU  - Ban M
FAU - Taylor, Craig J
AU  - Taylor CJ
FAU - Goodman, Reyna S
AU  - Goodman RS
FAU - Walsh, Emily
AU  - Walsh E
FAU - Wolfish, Cara S
AU  - Wolfish CS
FAU - Horton, Roger
AU  - Horton R
FAU - Traherne, James
AU  - Traherne J
FAU - Beck, Stephan
AU  - Beck S
FAU - Trowsdale, John
AU  - Trowsdale J
FAU - Caillier, Stacy J
AU  - Caillier SJ
FAU - Ivinson, Adrian J
AU  - Ivinson AJ
FAU - Green, Todd
AU  - Green T
FAU - Pobywajlo, Susan
AU  - Pobywajlo S
FAU - Lander, Eric S
AU  - Lander ES
FAU - Pericak-Vance, Margaret A
AU  - Pericak-Vance MA
FAU - Haines, Jonathan L
AU  - Haines JL
FAU - Daly, Mark J
AU  - Daly MJ
FAU - Oksenberg, Jorge R
AU  - Oksenberg JR
FAU - Hauser, Stephen L
AU  - Hauser SL
FAU - Compston, Alastair
AU  - Compston A
FAU - Hafler, David A
AU  - Hafler DA
FAU - Rioux, John D
AU  - Rioux JD
FAU - Sawcer, Stephen
AU  - Sawcer S
LA  - eng
GR  - R01 NS049477/NS/NINDS NIH HHS/United States
GR  - 048880/WT_/Wellcome Trust/United Kingdom
GR  - G0401569/MRC_/Medical Research Council/United Kingdom
GR  - 057097/WT_/Wellcome Trust/United Kingdom
GR  - NS026799/NS/NINDS NIH HHS/United States
GR  - R01 NS026799/NS/NINDS NIH HHS/United States
GR  - K08 NS46341/NS/NINDS NIH HHS/United States
GR  - NS032830/NS/NINDS NIH HHS/United States
GR  - R01 NS032830/NS/NINDS NIH HHS/United States
GR  - 588/MSS_/Multiple Sclerosis Society/United Kingdom
GR  - NS049477/NS/NINDS NIH HHS/United States
GR  - K08 NS046341/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (HLA-D Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-D Antigens/genetics
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics
MH  - Male
MH  - Microsatellite Repeats
MH  - Middle Aged
MH  - Multiple Sclerosis/*genetics
MH  - Polymorphism, Single Nucleotide
PMC - PMC2737610
EDAT- 2007/01/26 09:00
MHDA- 2007/06/02 09:00
CRDT- 2007/01/26 09:00
PHST- 2007/01/26 09:00 [pubmed]
PHST- 2007/06/02 09:00 [medline]
PHST- 2007/01/26 09:00 [entrez]
AID - 10.1002/ana.21063 [doi]
PST - ppublish
SO  - Ann Neurol. 2007 Mar;61(3):228-36. doi: 10.1002/ana.21063.