PMID- 17253161
OWN - NLM
STAT- MEDLINE
DCOM- 20070724
LR  - 20200930
IS  - 0963-9292 (Print)
IS  - 0963-9292 (Linking)
VI  - 16
IP  - 1
DP  - 2007 Feb
TI  - Endocrine disrupting compounds and echinoderms: new ecotoxicological sentinels 
      for the marine ecosystem.
PG  - 95-108
AB  - Echinoderms are valuable test species in marine ecotoxicology and offer a wide 
      range of biological processes appropriate for this approach. In spite of this 
      potential, available data in literature are still rather limited, particularly 
      with regard to the possible effects of endocrine disrupter compounds (EDCs). This 
      review presents echinoderms as useful models for ecotoxicological tests and gives 
      a brief overview of the most significant results obtained in recent years, 
      particularly in the context of the COMPRENDO EU project. In this research project 
      two different aspects of echinoderm physiology, plausibly regulated by humoral 
      mechanisms, were investigated: reproductive biology and regenerative development. 
      Selected EDCs suspected for their androgenic or antiandrogenic action were tested 
      at low concentrations. The results obtained so far showed that different 
      parameters such as regenerative growth, histological pattern, egg diameter and 
      gonad maturation were affected by the exposure to the selected compounds. These 
      results substantiate that reproductive and regenerative phenomena of echinoderms 
      can be considered valuable alternative models for studies on EDCs and confirm 
      that these compounds interfere with fundamental physiological processes, 
      including growth, development and reproductive competence.
FAU - Sugni, Michela
AU  - Sugni M
AD  - Dipartimento di Biologia, Universita degli Studi di Milano, Via Celoria 26, 
      I-20133 Milano, Italy. michela.sugni@unimi.it
FAU - Mozzi, Daniela
AU  - Mozzi D
FAU - Barbaglio, Alice
AU  - Barbaglio A
FAU - Bonasoro, Francesco
AU  - Bonasoro F
FAU - Candia Carnevali, Maria Daniela
AU  - Candia Carnevali MD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Ecotoxicology
JT  - Ecotoxicology (London, England)
JID - 9885956
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Echinodermata/*drug effects/physiology
MH  - Endocrine Disruptors/*toxicity
MH  - *Models, Animal
MH  - Regeneration/drug effects
MH  - Reproduction/drug effects
MH  - Seawater
MH  - Water Pollutants, Chemical/toxicity
RF  - 64
EDAT- 2007/01/27 09:00
MHDA- 2007/07/25 09:00
CRDT- 2007/01/27 09:00
PHST- 2007/01/27 09:00 [pubmed]
PHST- 2007/07/25 09:00 [medline]
PHST- 2007/01/27 09:00 [entrez]
AID - 10.1007/s10646-006-0119-8 [doi]
PST - ppublish
SO  - Ecotoxicology. 2007 Feb;16(1):95-108. doi: 10.1007/s10646-006-0119-8.