PMID- 17253955
OWN - NLM
STAT- MEDLINE
DCOM- 20070403
LR  - 20231120
IS  - 1547-3287 (Print)
IS  - 1547-3287 (Linking)
VI  - 15
IP  - 6
DP  - 2006 Dec
TI  - Oligodendrocyte progenitor cells derived from human embryonic stem cells express 
      neurotrophic factors.
PG  - 943-52
AB  - Oligodendrocyte progenitor cells (OPCs) derived from human embryonic stem (hES) 
      cells have been reported to remyelinate axons and improve locomotor function in a 
      rodent model of spinal cord injury. Although remyelination would be expected to 
      have a beneficial effect in spinal cord injury, neurotrophic factor expression 
      may also contribute to functional recovery. Neurotrophic factors could impact the 
      survival of axotomized neurons, as well as promote axonal regeneration in 
      interrupted conduction pathways. This study demonstrates that hES cell-derived 
      OPCs express functional levels of midkine, hepatocyte growth factor (HGF), 
      activin A, transforming growth factor-beta2 (TGF-beta2), and brain-derived 
      neurotrophic factor (BDNF), proteins with reported trophic effects on neurons. 
      The neurotrophic activity of hES cell-derived OPCs is further demonstrated by 
      stimulatory effects on neurite outgrowth of adult rat sensory neurons in vitro.
FAU - Zhang, Yi Wei
AU  - Zhang YW
AD  - Geron Corporation, Menlo Park, CA 94025, USA.
FAU - Denham, Jerrod
AU  - Denham J
FAU - Thies, R Scott
AU  - Thies RS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Culture Media, Serum-Free)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Cell Differentiation
MH  - Culture Media, Serum-Free
MH  - Embryonic Stem Cells/*cytology/*physiology
MH  - Gene Expression Profiling
MH  - Humans
MH  - Nerve Growth Factors/*genetics
MH  - Neurites/physiology/ultrastructure
MH  - Neurons, Afferent/cytology/*physiology
MH  - Oligodendroglia/*cytology/*physiology
EDAT- 2007/01/27 09:00
MHDA- 2007/04/04 09:00
CRDT- 2007/01/27 09:00
PHST- 2007/01/27 09:00 [pubmed]
PHST- 2007/04/04 09:00 [medline]
PHST- 2007/01/27 09:00 [entrez]
AID - 10.1089/scd.2006.15.943 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2006 Dec;15(6):943-52. doi: 10.1089/scd.2006.15.943.