PMID- 17255345
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20221207
IS  - 0300-5771 (Print)
IS  - 0300-5771 (Linking)
VI  - 36
IP  - 3
DP  - 2007 Jun
TI  - Life-course influences on health in British adults: effects of socio-economic 
      position in childhood and adulthood.
PG  - 532-9
AB  - BACKGROUND: Little evidence exists on the role of socio-economic position (SEP) 
      in early life on adult disease other than for cardiovascular mortality; data is 
      often retrospective. We assess whether childhood SEP influences disease risk in 
      mid-life, separately from the effect of adult position, and establish how 
      associations vary across multiple measures of disease risk. METHODS: Prospective 
      follow-up to adulthood of all born in England, Scotland and Wales during 1 week 
      in 1958, and with medical data at age 45 years (n = 9377). Outcomes include: 
      blood pressure, body mass index (BMI), glycosylated haemoglobin (HbA1c), total 
      and high density lipoprotein (HDL) cholesterol, triglycerides, fibrinogen, total 
      immunoglobulin E (IgE), one-second forced expiratory volume (FEV1), hearing 
      threshold (4 kHz), visual impairment, symptoms of depression and anxiety, chronic 
      widespread pain. RESULTS: Social class in childhood was associated with blood 
      pressure, BMI, HbA1c, HDL cholesterol, triglycerides, fibrinogen, FEV1, hearing 
      threshold, depressive symptoms and chronic widespread pain, with a general trend 
      of deteriorating health from class I to V. Adult social class was also associated 
      with these measures. Mutually adjusted analyses of child and adult social class 
      suggest that both contribute to disease risk in mid-life: in general, 
      associations for childhood class were as strong as for adult class. Individuals 
      with a manual class at both time-points tended to have the greatest health 
      deficits in adulthood. CONCLUSIONS: Adverse SEP in childhood is associated with a 
      poorer health profile in mid-adulthood, independently of adult social position, 
      and across diverse measures of disease risk and physical and mental functioning.
FAU - Power, Chris
AU  - Power C
AD  - Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 
      30 Guilford Street, London, UK. c.power@ich.ucl.ac.uk
FAU - Atherton, Kate
AU  - Atherton K
FAU - Strachan, David P
AU  - Strachan DP
FAU - Shepherd, Peter
AU  - Shepherd P
FAU - Fuller, Elizabeth
AU  - Fuller E
FAU - Davis, Adrian
AU  - Davis A
FAU - Gibb, Ian
AU  - Gibb I
FAU - Kumari, Meena
AU  - Kumari M
FAU - Lowe, Gordon
AU  - Lowe G
FAU - Macfarlane, Gary J
AU  - Macfarlane GJ
FAU - Rahi, Jugnoo
AU  - Rahi J
FAU - Rodgers, Bryan
AU  - Rodgers B
FAU - Stansfeld, Stephen
AU  - Stansfeld S
LA  - eng
GR  - G0000934/MRC_/Medical Research Council/United Kingdom
GR  - G0400546/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070125
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Int J Epidemiol. 2007 Jun;36(3):540-1. PMID: 17557780
CIN - Int J Epidemiol. 2007 Jun;36(3):481-3. PMID: 17675305
MH  - Adult
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Cardiovascular Diseases/epidemiology/etiology
MH  - England/epidemiology
MH  - Epidemiologic Methods
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - *Health Status
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant, Newborn
MH  - Lipids/blood
MH  - Male
MH  - Mental Disorders/epidemiology/etiology
MH  - Middle Aged
MH  - Respiration Disorders/epidemiology/etiology
MH  - Scotland/epidemiology
MH  - *Social Class
MH  - Wales/epidemiology
EDAT- 2007/01/27 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/01/27 09:00
PHST- 2007/01/27 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/01/27 09:00 [entrez]
AID - dyl310 [pii]
AID - 10.1093/ije/dyl310 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2007 Jun;36(3):532-9. doi: 10.1093/ije/dyl310. Epub 2007 Jan 25.