PMID- 17255346
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20220129
IS  - 0300-5771 (Print)
IS  - 0300-5771 (Linking)
VI  - 36
IP  - 3
DP  - 2007 Jun
TI  - Lifecourse influences on health among British adults: effects of region of 
      residence in childhood and adulthood.
PG  - 522-31
AB  - BACKGROUND: It has been suggested that early life exposures are important 
      determinants of geographical variations in adult diseases. We examined 
      inter-regional migrants in Britain to evaluate the relative importance of early 
      and recent exposures for adult cardiorespiratory risk factors, mental ill-health 
      and sensory function. METHODS: A total of 9023 persons born throughout England, 
      Scotland and Wales during 1 week in 1958 were followed periodically through 
      childhood into adulthood. At 44-45 years, height, body mass index (BMI), blood 
      pressure (BP), glycosylated haemoglobin, total and high-density lipoprotein (HDL) 
      cholesterol, triglycerides, fibrinogen, total immunoglobulin E (IgE), one-second 
      forced expiratory volume (FEV1), hearing threshold at 4 kHz, visual impairment, 
      symptoms of depression and anxiety, and chronic widespread pain were measured. 
      Analysis of migration between 12 regions included 3125 cohort members who were 
      examined in a region different to their birthplace. RESULTS: Height, BMI, 
      diastolic BP (DBP), FEV1, log-transformed IgE and hearing threshold varied by 
      region among non-migrants (each P < 0.05). Among inter-regional migrants, the 
      spatial associations with current region, independent of birthplace, followed 
      closely the geographical pattern shown among non-migrants for BMI, DBP and FEV1 
      (each P < 0.001). In contrast, of the 15 outcomes, only adult height was related 
      to region of birth, after adjustment for region of examination (P = 0.002) 
      CONCLUSIONS: Although individual disease risk is predicted by early life factors, 
      early exposures do not explain regional variations in cardiovascular and 
      respiratory risk factors among middle-aged adults in Britain. Geographical 
      inequalities in cardiorespiratory health are more strongly related to factors 
      associated with region of examination that influence obesity, BP and ventilatory 
      function.
FAU - Strachan, David P
AU  - Strachan DP
AD  - Division of Community Health Sciences, St George's University of London, Cranmer 
      Terrace, London, UK. d.strachan@sgul.ac.uk
FAU - Rudnicka, Alicja R
AU  - Rudnicka AR
FAU - Power, Chris
AU  - Power C
FAU - Shepherd, Peter
AU  - Shepherd P
FAU - Fuller, Elizabeth
AU  - Fuller E
FAU - Davis, Adrian
AU  - Davis A
FAU - Gibb, Ian
AU  - Gibb I
FAU - Kumari, Meena
AU  - Kumari M
FAU - Rumley, Ann
AU  - Rumley A
FAU - Macfarlane, Gary J
AU  - Macfarlane GJ
FAU - Rahi, Jugnoo
AU  - Rahi J
FAU - Rodgers, Bryan
AU  - Rodgers B
FAU - Stansfeld, Stephen
AU  - Stansfeld S
LA  - eng
GR  - G0000934/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070125
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Int J Epidemiol. 2007 Jun;36(3):540-1. PMID: 17557780
CIN - Int J Epidemiol. 2007 Jun;36(3):481-3. PMID: 17675305
MH  - Adult
MH  - Blood Pressure
MH  - Body Height
MH  - Body Mass Index
MH  - Cardiovascular Diseases/epidemiology/etiology
MH  - England/epidemiology
MH  - Epidemiologic Methods
MH  - Forced Expiratory Volume
MH  - *Health Status
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant, Newborn
MH  - Mental Disorders/epidemiology/etiology
MH  - Middle Aged
MH  - *Residence Characteristics
MH  - Respiration Disorders/epidemiology/etiology
MH  - Scotland/epidemiology
MH  - Transients and Migrants
MH  - Wales/epidemiology
EDAT- 2007/01/27 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/01/27 09:00
PHST- 2007/01/27 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/01/27 09:00 [entrez]
AID - dyl309 [pii]
AID - 10.1093/ije/dyl309 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2007 Jun;36(3):522-31. doi: 10.1093/ije/dyl309. Epub 2007 Jan 
      25.