PMID- 17255772
OWN - NLM
STAT- MEDLINE
DCOM- 20070301
LR  - 20131121
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 31
IP  - 2
DP  - 2007 Feb
TI  - Pulmonary light chain deposition disease: report of five cases and review of the 
      literature.
PG  - 267-76
AB  - Light chain deposition disease (LCDD) in the lung is a rare occurrence. We 
      describe 5 new cases of this entity, review the literature, and compare pulmonary 
      light chain deposits to pulmonary amyloidosis. In addition, we identified 17 
      patients with pulmonary LCDD in the literature with sufficient clinical 
      information to allow evaluation of clinical presentation, laboratory findings, 
      histologic appearance, and disease progression. In these 22 patients, 2 different 
      histologic patterns were appreciated: diffuse and nodular. A parallel with the 
      diffuse and nodular forms of pulmonary amyloidosis is suggested. The 10 patients 
      with nodular LCDD had an overall better prognosis compared with the 12 patients 
      with diffuse pulmonary LCDD. However, when compared to what is reported in the 
      literature for nodular pulmonary amyloidosis, the patients with nodular LCDD had 
      a higher incidence of an associated lymphoproliferative and/or plasma cell 
      dyscrasia and renal failure. Light chain deposits in the lung are histologically 
      similar to amyloid but are not Congophilic. Their electron microscopic appearance 
      is distinctly different with fibrils in amyloid and granular deposits in LCDD. As 
      the diffuse forms of LCDD and amyloidosis have a similarly poor prognosis, 
      differentiating the 2 entities is probably not critical. However, when present as 
      nodules, LCDD is more frequently associated with an underlying plasma cell 
      dyscrasia or renal failure than is amyloidosis, and therefore the distinction may 
      be clinically important.
FAU - Bhargava, Parul
AU  - Bhargava P
AD  - Department of Pathology at Beth Israel Deaconess Medical Center, Boston MA 02215, 
      USA. pbhargav@bidmc.harvard.edu
FAU - Rushin, Jeanne M
AU  - Rushin JM
FAU - Rusnock, Eileen J
AU  - Rusnock EJ
FAU - Hefter, Lawrence G
AU  - Hefter LG
FAU - Franks, Teri J
AU  - Franks TJ
FAU - Sabnis, Sharda G
AU  - Sabnis SG
FAU - Travis, William D
AU  - Travis WD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Amyloid)
RN  - 0 (Immunoglobulin Light Chains)
RN  - 3U05FHG59S (Congo Red)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloid/analysis/metabolism
MH  - Amyloidosis/metabolism/pathology
MH  - Congo Red
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism/ultrastructure
MH  - Immunohistochemistry
MH  - Lung Diseases/metabolism/*pathology
MH  - Male
MH  - Microscopy, Electron, Transmission
MH  - Microscopy, Polarization
MH  - Paraproteinemias/metabolism/*pathology
EDAT- 2007/01/27 09:00
MHDA- 2007/03/03 09:00
CRDT- 2007/01/27 09:00
PHST- 2007/01/27 09:00 [pubmed]
PHST- 2007/03/03 09:00 [medline]
PHST- 2007/01/27 09:00 [entrez]
AID - 00000478-200702000-00013 [pii]
AID - 10.1097/01.pas.0000213358.18380.d2 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2007 Feb;31(2):267-76. doi: 10.1097/01.pas.0000213358.18380.d2.